EURYCOMALACTONE(P)

Product Name: EURYCOMALACTONE(P)
CAS No.: 23062-24-0
Chemical Name: EURYCOMALACTONE(P)
Synonyms: Eurycomalatone;Eurycomalactone;EURYCOMALACTONE(P);EURYCOMALACTONE(AS);EURYCOMALACTONE(SH);Eurycomalactone, 10 mM in DMSO;(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione;(1R,2R,5S,5aR,7aS,11S,11aS,11bR)-1,11-dihydroxy-5a,8,11a,12-tetramethyl-1,5,5a,7,7a,11,11a,11b-octahydro-2,5-methanonaphtho[1,2-d]oxepine-4,6,10(2H)-trione;(1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-1,11-Dihydroxy-5a,8,11a,12-tetramethyl-1,5,5a,7,7a,11,11a,11b-octahydro-2,5-methanonaphtho[1,2-d]oxepine-4,6,10(2H)-trione;DNA double-strand,Eurycomalactone,NF-κB,protein synthesis,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cisplatin,cyclin D1,inhibit,Eurycoma longifolia Jack
CBNumber: CB8506957
Molecular Formula: C19H24O6
Formula Weight: 348.39
MOL File: 23062-24-0.mol

More

Less

EURYCOMALACTONE(P) Property

Melting point:: 267～270℃
Boiling point:: 588.1±50.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
form: Solid
pka: 12.22±0.70(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 300261
Product name: Eurycomalactone
Packaging: 5mg
Price: $581
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259231
Product name: Eurycomalactone
Purity: 94%
Packaging: 10mg
Price: $591.6
Updated: 2021/12/16

ChemScene

Product number: CS-0032756
Product name: Eurycomalactone
Packaging: 1mg
Price: $210
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259231
Product name: Eurycomalactone
Purity: 94%
Packaging: 5mg
Price: $433.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0003247
Product name: EURYCOMALACTONE
Purity: 95.00%
Packaging: 5MG
Price: $504.53
Updated: 2021/12/16

More

Less

EURYCOMALACTONE(P) Chemical Properties,Usage,Production

Uses

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].

Definition

ChEBI: Eurycomalactone is a steroid lactone.

References

[1] Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G?/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. DOI:10.3727/096504019X15736439848765
[2] Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. DOI:10.3892/or.2020.7710
[3] Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. DOI:10.1021/acs.jnatprod.7b00503

EURYCOMALACTONE(P) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

EURYCOMALACTONE(P) Suppliers

China 69 United States 6 Global 75

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5093
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5095
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

23062-24-0, EURYCOMALACTONE(P)Related Search:

4-Hexanolide Polycaprolactone 13-alpha-(21)-Epoxyeurycomanone EURYCOMANONE 14,15-beta-dihydroxyklaineanone 8-OXOTRIDECANOIC ACID 2-Ketopelargonic acid ethyl ester (2-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER 4-Ketoundecanoicacid (-)-DIHYDROCRAVONE 3-HEPTYLDIHYDRO-5-METHYL-2(3H)-FURANONE (+)-DIHYDROCARVONE EURYCOMALACTONE(P) ETHYL 2-CYCLOHEXANONEACETATE

EURYCOMALACTONE(P)

(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione

Eurycomalatone

EURYCOMALACTONE(SH)

EURYCOMALACTONE(AS)

Eurycomalactone

2,5-Methanonaphth[1,2-d]oxepin-4,6,10(2H)-trione, 1,5,5a,7,7a,11,11a,11b-octahydro-1,11-dihydroxy-5a,8,11a,12-tetramethyl-, (1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-

DNA double-strand,Eurycomalactone,NF-κB,protein synthesis,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cisplatin,cyclin D1,inhibit,Eurycoma longifolia Jack

(1R,2R,5S,5aR,7aS,11S,11aS,11bR)-1,11-dihydroxy-5a,8,11a,12-tetramethyl-1,5,5a,7,7a,11,11a,11b-octahydro-2,5-methanonaphtho[1,2-d]oxepine-4,6,10(2H)-trione

Eurycomalactone, 10 mM in DMSO

(1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-1,11-Dihydroxy-5a,8,11a,12-tetramethyl-1,5,5a,7,7a,11,11a,11b-octahydro-2,5-methanonaphtho[1,2-d]oxepine-4,6,10(2H)-trione

23062-24-0