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4-Hexanolide

Aroma
Product Name
4-Hexanolide
CAS No.
695-06-7
Chemical Name
4-Hexanolide
Synonyms
2(3H)-Furanone, 5-ethyldihydro-;γ-Hexalactone;GAMMA-HEXALACTONE;5-Ethyldihydro-2(3H)-furanone;GAMMA-CAPROLACTONE;5-Ethyldihydrofuran-2(3H)-one;hexan-4-olide;Dihydro-5-ethyl-2(3H)-furanone;FEMA 2556;g-Hexanolactone
CBNumber
CB2387024
Molecular Formula
C6H10O2
Formula Weight
114.14
MOL File
695-06-7.mol
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4-Hexanolide Property

Melting point:
-18°C
Boiling point:
219 °C(lit.)
Density 
1.023 g/mL at 25 °C(lit.)
vapor pressure 
2.4hPa at 20℃
FEMA 
2556 | GAMMA-HEXALACTONE
refractive index 
n20/D 1.439(lit.)
Flash point:
209 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.023
Odor
at 10.00 % in dipropylene glycol. herbal coconut sweet coumarin tobacco
Odor Type
tonka
Water Solubility 
77g/L at 20℃
JECFA Number
223
BRN 
107260
LogP
0.3 at 20℃
CAS DataBase Reference
695-06-7(CAS DataBase Reference)
NIST Chemistry Reference
2(3H)-Furanone, 5-ethyldihydro-(695-06-7)
EPA Substance Registry System
2(3H)-Furanone, 5-ethyldihydro- (695-06-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36
WGK Germany 
2
RTECS 
LU4220000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W255611
Product name
γ-Hexalactone
Purity
natural,97%,FG
Packaging
100g
Price
$702
Updated
2024/03/01
Sigma-Aldrich
Product number
W255611
Product name
γ-Hexalactone
Purity
natural,97%,FG
Packaging
500g
Price
$2490
Updated
2024/03/01
Sigma-Aldrich
Product number
W255602
Product name
γ-Hexalactone
Purity
≥98%,FCC,FG
Packaging
1kg
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
W255602
Product name
γ-Hexalactone
Purity
≥98%,FCC,FG
Packaging
10Kg
Price
$1520
Updated
2024/03/01
Sigma-Aldrich
Product number
68554
Product name
γ-Hexalactone
Purity
analytical standard
Packaging
1ml
Price
$101
Updated
2024/03/01
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4-Hexanolide Chemical Properties,Usage,Production

Aroma

Warm, powerfully herbaceous, sweet "Tobacco-like", coumannic type odor. Sweet, powerful, warm-herbaceous, Coumarin-Caramel taste.

Description

gamma-Hexalactone has a warm, powerful, herbaceous, sweet odor and a sweet, coumarin-caramel taste. May be prepared by reduction of sorbic acid using Zn, Sn, or SnCl2 and concentrated HCL in acetic acid solution at 85°C; from ethylene oxide and sodio-malonic ester; also from propyl alcohol and methylacrylate in the presence of di-tert-butyl peroxide.

Chemical Properties

γ-Hexalactone has a sweet, herbaceous, warm, powerful, odor, with a sweet, coumarin-caramel taste. This compound is also described to have odor as sweet, creamy, lactonic, tobacco and coumarin-like with green coconut nuances.

Chemical Properties

4-Hexanolide is colorless liquid. Very slightly soluble in water, soluble in alcohol, Propylene glycol and oils.

Occurrence

Reported found in apple juice, apricot, orange juice, guava, raisin, papaya, peach, pineapple, berries, asparagus, peas, potato, tomato, breads, cheeses, butter, milk, chicken fat, cooked beef, cooked pork, beer, cognac, grape wines, cocoa, tea, filberts, pecans, passion fruit, Japanese plum, beans, mushroom, starfruit, mango, dried fig, prickly pear, licorice, soursop, Cape gooseberry, nectarines, quince, pawpaw and other sources.

Uses

γ-Hexalactone may be used as an analytical standard for the determination of the analyte in wine, fruits, biological samples, meat products, and e-cigarette refill solutions by various chromatography techniques.

Uses

4-Hexanolide was used as curing agent for diglycidyl ether of bisphenol A with ytterbium triflate as an initiator.

Uses

γ-Caprolactone was used as curing agent for diglycidyl ether of bisphenol A with ytterbium triflate as an initiator.

Preparation

By reduction of sorbic acid using Zn, Sn or SnCl2 and concentrated HCl in acetic acid solution at 85°C; from ethylene oxide and sodio-malonic ester; also from propyl alcohol and methylacrylate in the presence of di-tert-butyl peroxide

Definition

4-Hexanolide is a gamma-lactone that is oxolan-2-one substituted by an ethyl group at position 5.

Application

4-Hexanolide finds some use in perfume compositions as a modifier for Coumarin, in Lavender and Fougere perfumes, and in many other types where Oakmoss is used as a sweetener for mossy notes. This material is more widely used in flavors, where its power and creamy sweetness is utilized for imitation Butter, Honey, Vanilla, Caramel and in fruit complexes and Tobacco flavorings.
The concentration used may vary from 0,1 ppm to 20 ppm in most of the common finished products, except in ice cream where it may be as high as 60 to 90 ppm. It performs very well with Vanillin as a synergist for the Vanilla and Cream-like flavor, an effect previously supplied by Coumarin.

Aroma threshold values

Detection: 1.6 ppm

Taste threshold values

Taste characteristics at 75 ppm: sweet, creamy, vanilla-like with green lactonic powdery nuances

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 2111, 1987 DOI: 10.1016/S0040-4039(00)96056-8

General Description

γ-Hexalactone is a volatile flavoring compound largely present in food and beverage products, fruits, vegetables, etc.

Biochem/physiol Actions

Taste at 5-10ppm

4-Hexanolide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hexanolide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
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View Lastest Price from 4-Hexanolide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Hexanolide 695-06-7
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-27
Hebei Weibang Biotechnology Co., Ltd
Product
4-Hexanolide 695-06-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Hebei Weibang Biotechnology Co., Ltd
Product
4-Hexanolide 695-06-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01

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