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SL0101

Product Name
SL0101
CAS No.
77307-50-7
Chemical Name
SL0101
Synonyms
SL0101;SL 0101-1;RSK Inhibitor, SL0101;3'',4''-Di-O-acetylafzelin;SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
CBNumber
CB8507631
Molecular Formula
C25H24O12
Formula Weight
516.45
MOL File
77307-50-7.mol
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SL0101 Property

Melting point:
128-132°C
Boiling point:
753.0±60.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Acetone (Slightly), Methanol (Slightly)
form 
Yellow solid
pka
6.20±0.40(Predicted)
color 
Pale Yellow to Brown
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Safety

HS Code 
2940000080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559285
Product name
RSK Inhibitor, SL0101
Packaging
1mg
Price
$360
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
1mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
5mg
Price
$395
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
10mg
Price
$547
Updated
2024/03/01
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SL0101 Chemical Properties,Usage,Production

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Uses

SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

storage

-20°C

SL0101 Preparation Products And Raw materials

Raw materials

Preparation Products

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SL0101 Suppliers

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77307-50-7, SL0101Related Search:

Sodium levothyroxine Ceteareth-5 Scutellarin SCUTELLAREIN KAEMPFEROL 3-O-GLUCORHAMNOSIDE SL0101

  • SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1
  • RSK Inhibitor, SL0101
  • 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)
  • SL0101
  • 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside
  • 3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone
  • 3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone
  • SL 0101-1
  • 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
  • 3'',4''-Di-O-acetylafzelin
  • 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • (2S,3S,4S,5R,6S)-6-((5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate
  • 77307-50-7
  • 13C & 2H Sugars
  • Carbohydrates & Derivatives
  • Inhibitors