ChemicalBook > CAS DataBase List > SL0101

SL0101

Product Name
SL0101
CAS No.
77307-50-7
Chemical Name
SL0101
Synonyms
SL0101;SL 0101-1;RSK Inhibitor, SL0101;3'',4''-Di-O-acetylafzelin;SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
CBNumber
CB8507631
Molecular Formula
C25H24O12
Formula Weight
516.45
MOL File
77307-50-7.mol
More
Less

SL0101 Property

Melting point:
128-132°C
Boiling point:
753.0±60.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Acetone (Slightly), Methanol (Slightly)
form 
Yellow solid
pka
6.20±0.40(Predicted)
color 
Pale Yellow to Brown
More
Less

Safety

HS Code 
2940000080
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559285
Product name
RSK Inhibitor, SL0101
Packaging
1mg
Price
$360
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
1mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
5mg
Price
$395
Updated
2024/03/01
Cayman Chemical
Product number
11704
Product name
SL 0101-1
Purity
≥98%
Packaging
10mg
Price
$547
Updated
2024/03/01
More
Less

SL0101 Chemical Properties,Usage,Production

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Uses

SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

storage

-20°C

SL0101 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SL0101 Suppliers

Canada 1 China 64 India 1 United Kingdom 1 United States 11 Global 78
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4870
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9272
Advantage
58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
Email
cooperation@kean-chem.com
Country
China
ProdList
40066
Advantage
58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33338
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Shize Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shizezjp@163.com
Country
CHINA
ProdList
6174
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6672
Advantage
58
Beijing Sizhengbai Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
marketing@4abio.com
Country
CHINA
ProdList
6401
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Hangzhou Lianke Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6349
Advantage
58
Beijing Zhijie Fangyuan Technology Co., Ltd.
Tel
--
Fax
--
Email
15810200961@163.com
Country
CHINA
ProdList
6984
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58
Shanghai Boyi Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15800446246@163.com
Country
CHINA
ProdList
5416
Advantage
58
Beijing Xiangsheng Xingye Technology Co., Ltd.
Tel
--
Fax
--
Email
xs_bio@163.com
Country
CHINA
ProdList
5130
Advantage
58
Shanghai yiji industries Co., Ltd.
Tel
--
Fax
--
Email
yiji01@foxmail.com
Country
China
ProdList
6289
Advantage
50
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58
Shenzhen Branch Science and Technology Co., Ltd.
Tel
--
Fax
--
Email
zikerbio@163.com
Country
CHINA
ProdList
6478
Advantage
58
Beijing Shengke Boyuan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
978560024@qq.com
Country
CHINA
ProdList
6005
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
market@xlswkj.com
Country
CHINA
ProdList
6793
Advantage
58
Shanghai Benrui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
john.st@163.com
Country
CHINA
ProdList
1471
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6518
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
--
Email
3007606172@qq.com
Country
CHINA
ProdList
6002
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58

77307-50-7, SL0101Related Search:

Sodium levothyroxine Ceteareth-5 Scutellarin SCUTELLAREIN KAEMPFEROL 3-O-GLUCORHAMNOSIDE SL0101

  • SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1
  • RSK Inhibitor, SL0101
  • 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)
  • SL0101
  • 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside
  • 3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone
  • 3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone
  • SL 0101-1
  • 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
  • 3'',4''-Di-O-acetylafzelin
  • 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • (2S,3S,4S,5R,6S)-6-((5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate
  • 77307-50-7
  • 13C & 2H Sugars
  • Carbohydrates & Derivatives
  • Inhibitors