ChemicalBook > CAS DataBase List > SL0101

SL0101

Product Name: SL0101
CAS No.: 77307-50-7
Chemical Name: SL0101
Synonyms: SL0101;SL 0101-1;RSK Inhibitor, SL0101;3'',4''-Di-O-acetylafzelin;SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
CBNumber: CB8507631
Molecular Formula: C25H24O12
Formula Weight: 516.45
MOL File: 77307-50-7.mol

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SL0101 Property

Melting point:: 128-132°C
Boiling point:: 753.0±60.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Acetone (Slightly), Methanol (Slightly)
form: Yellow solid
pka: 6.20±0.40(Predicted)
color: Pale Yellow to Brown

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Safety

HS Code: 2940000080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559285
Product name: RSK Inhibitor, SL0101
Packaging: 1mg
Price: $370
Updated: 2025/07/31

Cayman Chemical

Product number: 11704
Product name: SL 0101-1
Purity: ≥98%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 11704
Product name: SL 0101-1
Purity: ≥98%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 11704
Product name: SL 0101-1
Purity: ≥98%
Packaging: 5mg
Price: $395
Updated: 2024/03/01

Cayman Chemical

Product number: 11704
Product name: SL 0101-1
Purity: ≥98%
Packaging: 10mg
Price: $547
Updated: 2024/03/01

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SL0101 Chemical Properties,Usage,Production

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC₅₀ value of 89 nM (K_i = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G₁ phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Uses

SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

storage

-20°C

References

[1] JEFFREY A. SMITH. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.[J]. Cancer research, 2005, 146 1: 1027-1034. DOI: 10.1158/0008-5472.1027.65.3
[2] MICHAEL D GODENY Peter P S. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.[J]. American journal of physiology. Cell physiology, 2006, 291 6: C1308-17. DOI: 10.1152/ajpcell.00618.2005

SL0101 Preparation Products And Raw materials

Raw materials

Preparation Products

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77307-50-7, SL0101Related Search:

Sodium levothyroxine Ceteareth-5 Scutellarin SCUTELLAREIN KAEMPFEROL 3-O-GLUCORHAMNOSIDE SL0101

SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1

RSK Inhibitor, SL0101

3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)

SL0101

2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one

2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside

3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone

3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone

SL 0101-1

3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

3'',4''-Di-O-acetylafzelin

4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-

(2S,3S,4S,5R,6S)-6-((5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate

77307-50-7

13C & 2H Sugars

Carbohydrates & Derivatives

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