ChemicalBook > CAS DataBase List > 3-O-Ethyl-L-ascorbic acid

3-O-Ethyl-L-ascorbic acid

Product Name: 3-O-Ethyl-L-ascorbic acid
CAS No.: 86404-04-8
Chemical Name: 3-O-Ethyl-L-ascorbic acid
Synonyms: ETHYL ASCORBIC ACID;VCE;vitaMin C ethyl ether;VC ethyl ether;3-O-Ethyl Ascorbyl Ether;3-0-Ethyl Ascorbic acid;Ethyl ascorbyl ether;(R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one;(5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one;LGB-VCE
CBNumber: CB8511566
Molecular Formula: C8H12O6
Formula Weight: 204.18
MOL File: 86404-04-8.mol

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3-O-Ethyl-L-ascorbic acid Property

Melting point:: 112.0 to 116.0 °C
Boiling point:: 551.5±50.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Sealed in dry,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 8.89±0.40(Predicted)
color: White to Off-White
optical activity: 46.1°(C=0.01 g/mL, MeOH, 20°C, 589nm)
InChI: InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1
InChIKey: ZGSCRDSBTNQPMS-UJURSFKZSA-N
SMILES: O(CC)C1=C(O)C(=O)O[C@@H]1[C@H](CO)O
LogP: -0.8--0.64 at 20-25℃ and pH7
Surface tension: 69-72.4mN/m at 1g/L and 20℃

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Safety

HS Code: 2936.27.0000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS009203
Product name: 3-o-Ethyl-<SC>L</SC>-ascorbic acid
Purity: AldrichCPR
Packaging: 100 mg
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: E0926
Product name: 3-O-Ethyl-L-ascorbic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: E0926
Product name: 3-O-Ethyl-L-ascorbic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $144
Updated: 2025/07/31

TRC

Product number: E922013
Product name: 3-O-Ethyl-L-ascorbic Acid
Packaging: 100mg
Price: $85
Updated: 2021/12/16

Chem-Impex

Product number: 31932
Product name: 3-O-Ethyl-L-ascorbicacid,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $11.2
Updated: 2021/12/16

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3-O-Ethyl-L-ascorbic acid Chemical Properties,Usage,Production

Description

3-O-Ethyl-L-ascorbic acid is a product of ascorbic acid-3-O-ethylation. It has a simple molecular structure and is easily absorbed by the skin. After entering the dermis through the stratum corneum of the skin, it is easily decomposed by the biological enzymes in the human body. The effect of ascorbic acid effectively solves the fat solubility problem of ascorbic acid, and is widely used in cosmetics as a whitening agent and antioxidant.

Uses

3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-hydroxyacetophenone solution. It could be a useful stabilizing agent for a para-hydroxyacetophenone solution.

Definition

ChEBI: 3-O-ethyl-l-ascorbic acid (EA) is a butenolide. It is an l-ascorbic acid derivative with an ethyl group at the third carbon position.

Health effects

3-O-ethyl-L-ascorbic acid improves the molecules' stability and its transportation efficacy to the skin, being absorbed faster and better. Additionally, it is less irritating to the skin. Cosmetic case studies demonstrate that they have skin brightening, collagen stimulating, and antioxidant properties.

Mechanism of action

VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And Chemicalbook and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.

Synthesis

The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114??C.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 9, p. 1618 - 1623
[2] Patent: CN105367524, 2016, A. Location in patent: Paragraph 0035; 0038
[3] Patent: WO2008/44809, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2010/56809, 2010, A1. Location in patent: Page/Page column 3
[5] Patent: WO2008/44809, 2008, A1. Location in patent: Page/Page column 10-11

3-O-Ethyl-L-ascorbic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-O-Ethyl-L-ascorbic acid manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: 3-O-Ethyl-L-ascorbic acid 86404-04-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2025-11-21

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Product: 3-O-Ethyl-L-ascorbic acid 86404-04-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 1kg/5kg25kg
Release date: 2025-09-16

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 3-O-Ethyl-L-ascorbic acid 86404-04-8
Price: US $49.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000
Release date: 2025-08-28

86404-04-8, 3-O-Ethyl-L-ascorbic acidRelated Search:

4-Ethoxyphenol Ethyl formate Erythorbic Acid Ethyl acrylate Ethylparaben Ethylbenzene tert-Butyl ethyl ether Calcium ascorbate dihydrate ASCORBATE OXIDASE Furan 1-Hydroxyethylidene-1,1-diphosphonic acid Ethoxyquin Ethyl acetate Ethanol CHLOROPHOSPHONAZO III acetic acid, triethoxy-, ethyl ester Ascorbic Acid 1,1'-Thiobisethane

3-O-Ethyl Ascorbyl Ether

3-O-Ethyl-L-ascorbic Acid

ETHYL ASCORBIC ACID

3-o-ethyl-l-ascorbic acid

3-O-ETHYLASCORBICACID

(5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-ethoxy-3-hydroxy-5H-furan-2-one

(5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one

(R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one

(5R)-5-(1,2-dihydroxyethyl)-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one

(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one (non-preferred naMe)

3-O-Ethyl vitaMin C ester

VC ethyl ether

vitaMin C ethyl ether

(5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-e

3-O-Ethyl-L-ascorbic acid VC ethyl ether

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3-O-Ethyl-L-ascorbic

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3-O-Ethyl-L-ascorbic Acid, >=99%

ETHYL ASCORBIC

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Ethyl ascorbyl ether

Ethyl Vitamin C

LGB-VCE

3-o-EthyL

3-O-Ethyl-L-ascorbicAcid&gt

L-Ascorbic acid, 3-O-ethyl-

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3-o-ETHHYL ASCORBIC ACID

Skin Whitening VCE

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3-O-Ethyl-L-ascorbic acid cas 86404-04-8

High Quality 3-O-Ethyl-L-Ascorbic Acid API with CAS: 86404-04-8

3-0-Ethyl Ascorbic acid

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3-0-Ethyl-L-ascorbic acid

Ethyl Ascorbic Acid (VCE)

Ethyl VC

Ethyl ascorbate ether

3-O-Ethyl-L-ascorbic acid(VCE)

Ethyl Ascorbic Acid Powder

Ethyl Ascorbic Acid 3-O-Ethyl ascorbic acid ether

Vitamin C Impurity 32

3-O-Ethyl Ascorbyl Ether|Ethyl Ascorbic Acid

(5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one

Ethyl ether of vitamin C

3-o-Ethyl-<sc>L</sc>-ascorbic acid

3-O-Ethyl-L-ascorbic acid VC

Ethyl ascorbic acid 99%

3-O-Ethyl Ascorbic Acid Ether

VCE ( 3-O-Ethyl-L-ascorbic acid )

86404-04-8

85404-04-8

86404-04-0

96404-04-8

556-67-4