ERK1/2 inhibitor 1

Product Name: ERK1/2 inhibitor 1
CAS No.: 2095719-90-5
Chemical Name: ERK1/2 inhibitor 1
Synonyms: ERK1/2 INHIBITOR 1;ERK1/2 inhibitor 1, 10 mM in DMSO;ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1;(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-
CBNumber: CB85540361
Molecular Formula: C29H32ClN5O4
Formula Weight: 550.06
MOL File: 2095719-90-5.mol

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ERK1/2 inhibitor 1 Property

Density: 1.344±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (454.50 mM; Need ultrasonic)
pka: 13.73±0.46(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0044721
Product name: ERK1/2inhibitor1
Purity: 99.16%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0044721
Product name: ERK1/2inhibitor1
Purity: 99.16%
Packaging: 10mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0044721
Product name: ERK1/2inhibitor1
Purity: 99.16%
Packaging: 50mg
Price: $2550
Updated: 2021/12/16

ChemScene

Product number: CS-0044721
Product name: ERK1/2inhibitor1
Purity: 99.16%
Packaging: 100mg
Price: $3550
Updated: 2021/12/16

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ERK1/2 inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

References

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.

ERK1/2 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ERK1/2 inhibitor 1 Suppliers

China 14 United States 3 Global 17

TargetMol Chemicals Inc.

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Aladdin Scientific

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2095719-90-5, ERK1/2 inhibitor 1Related Search:

ERK1/2 INHIBITOR 1

2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-

ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1

(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide

ERK1/2 inhibitor 1, 10 mM in DMSO

2095719-90-5

C29H32ClN5O4