ChemicalBook > CAS DataBase List > Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
- Product Name
- Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
- CAS No.
- 1606974-33-7
- Chemical Name
- Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
- Synonyms
- BPN14770;Zatolmilast;Zatolmilast (BPN14770);Zatolmilast, 10 mM in DMSO;Zatolmilast (BPN14770) ，S6844;Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit;2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid;Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
- CBNumber
- CB85552252
- Molecular Formula
- C21H15ClF3NO2
- Formula Weight
- 405.8
- MOL File
- 1606974-33-7.mol
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Property
- Boiling point:
- 514.4±50.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 260 mg/mL (640.71 mM)
- pka
- 4.27±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Axon Medchem
- Product number
- Axon3148
- Product name
- BPN14770
- Purity
- 99%
- Packaging
- 5mg
- Price
- $132
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon3148
- Product name
- BPN14770
- Purity
- 99%
- Packaging
- 2x5mg
- Price
- $220
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066529
- Product name
- BPN14770
- Purity
- 99.39%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066529
- Product name
- BPN14770
- Purity
- 99.39%
- Packaging
- 10mg
- Price
- $520
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066529
- Product name
- BPN14770
- Purity
- 99.39%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Chemical Properties,Usage,Production
Uses
Zatolmilast is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor for the treatment of fragile X syndrome and other brain disorders.
in vivo
Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
?
Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].
| Animal Model: | C57Bl6 mice[2] |
| Dosage: | 0.1, 0.3, 1, 3, 10, 30 mg/kg |
| Administration: | p.o.; 24?hours |
| Result: | Significantly improved novel object discrimination at doses above 0.3 mg/kg. |
IC 50
PDE4D3: 7.4 nM (IC50); PDE4D7: 7.8 nM (IC50)
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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View Lastest Price from Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- BPN14770 1606974-33-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2025-08-31