ATG4B antibody
Source Reactivity Background References- Product Name
- ATG4B antibody
- Chemical Name
- ATG4B antibody
- Synonyms
- ATG4B antibody
- CBNumber
- CB85606618
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb126738
- Product name
- ATG4B antibody
- Purity
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 25μg(Trial Size)
- Price
- $119
- Updated
- 2021/12/16
- Product number
- orb126738
- Product name
- ATG4B antibody
- Purity
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $272
- Updated
- 2021/12/16
- Product number
- orb160051
- Product name
- Atg4b antibody
- Purity
- Affinity-purified by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $280.5
- Updated
- 2021/12/16
- Product number
- orb126738
- Product name
- ATG4B antibody
- Purity
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 200μg
- Price
- $391
- Updated
- 2021/12/16
- Product number
- orb194038
- Product name
- ATG4B antibody
- Purity
- Immunogen affinity purified
- Packaging
- 100μL
- Price
- $445.4
- Updated
- 2021/12/16
ATG4B antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes. Formation of autophagic vesicles requires a pair of essential ubiquitin-like conjugation systems, Atg12-Atg5 and Atg8-phosphatidylethanolamine, which are widely conserved in eukaryotes. Numerous mammalian counterparts to yeast Atg proteins have been described, including three Atg8 proteins and four Atg4 homologs. The cysteine protease Atg4 is pivotal to autophagosome membrane generation and regulation. Atg4 primes the Atg8 homolog for lipidation by cleaving its carboxy terminus and exposing its glycine residue for E1-like enzyme Atg7. The Atg8 homolog is transferred to the E2-like enzyme Atg3 before forming the Atg8-PE conjugate. During later stages of autophagy, Atg4 can reverse this lipidation event by cleaving PE, thereby recycling the Atg8 homolog.While Atg4B displays a broad specificity for Atg8 homologues, it preferentially cleaves LC3. Mutation in the corresponding Atg4B gene can be associated with strong inhibition of autophagosome formation. An excess of inactive Atg4B blocks lipidation of Atg8 homologues and inhibits autophagy. This makes Atg4B a potential tool for characterization of the isolation membrane and other autophagy studies.
References
[1] Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
[2] Ohsumi, Y. (2001) Nat Rev Mol Cell Biol 2, 211-6.
[3] Kabeya, Y. et al. (2000) EMBO J 19, 5720-8.
[4] Kabeya, Y. et al. (2004) J Cell Sci 117, 2805-12.
[5] Mariño, G. et al. (2003) J Biol Chem 278, 3671-8.
[6] Sou, Y.S. et al. (2008) Mol Biol Cell 19, 4762-75.
[7] Hemelaar, J. et al. (2003) J Biol Chem 278, 51841-50.
[8] Kabeya, Y. et al. (2004) J Cell Sci 117, 2805-12.
[9] Tanida, I. et al. (2004) J Biol Chem 279, 36268-76.
[10] Fujita, N. et al. (2008) Mol Biol Cell 19, 4651-9.
ATG4B antibody Preparation Products And Raw materials
Raw materials
Preparation Products
ATG4B antibody Suppliers
- Tel
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