SYK Antibody
Source Reactivity Background References- Product Name
- SYK Antibody
- Chemical Name
- SYK Antibody
- Synonyms
- SYK Antibody;Mouse Monoclonal SYK Antibody
- CBNumber
- CB85699010
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb11439
- Product name
- Syk antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb11439
- Product name
- Syk antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
SYK Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse
Background
Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells. Syk interacts with immunoreceptor tyrosine-based activation motifs located in the cytoplasmic domains of immune receptors. It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. There is also evidence of a role for Syk in nonimmune cells and investigators have indicated that Syk is a potential tumor suppressor in human breast carcinomas. Tyr323 is a negative regulatory phosphorylation site within the SH2-kinase linker region in Syk. Phosphorylation at Tyr323 provides a direct binding site for the TKB domain of Cbl. Tyr352 of Syk is involved in the association of PLCγ1. Tyr525 and Tyr526 are located in the activation loop of the Syk kinase domain; phosphorylation at Tyr525/526 of human Syk is essential for Syk function.
References
[1] Cheng, A.M. and Chan, A.C. (1997) Curr Opin Immunol 9, 528-33.
[2] Kurosaki, T. (1997) Curr Opin Immunol 9, 309-18.
[3] Chu, D.H. et al. (1998) Immunol Rev 165, 167-80.
[4] Turner, M. et al. (2000) Immunol Today 21, 148-54.
[5] Coopman, P.J. et al. (2000) Nature 406, 742-7.
[6] Deckert, M. et al. (1998) J Biol Chem 273, 8867-74.
[7] Rao, N. et al. (2001) EMBO J 20, 7085-95.
[8] Law, C.L. et al. (1996) Mol Cell Biol 16, 1305-15.
[9] Zhang, J. et al. (2000) J Biol Chem 275, 35442-7.
SYK Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
SYK Antibody Suppliers
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