PS 210
- Product Name
- PS 210
- CAS No.
- 1221962-86-2
- Chemical Name
- PS 210
- Synonyms
- PS 210;PS210 ，S3462;PS210, 10 mM in DMSO;2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid;2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid;2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid;Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-;pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit
- CBNumber
- CB85867297
- Molecular Formula
- C19H15F3O5
- Formula Weight
- 380.31
- MOL File
- 1221962-86-2.mol
PS 210 Property
- Boiling point:
- 577.9±50.0 °C(Predicted)
- Density
- 1.400±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);262.94(Max Conc. mM)
- form
- A crystalline solid
- pka
- 2.93±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- DC21536
- Product name
- PS210
- Purity
- >98%
- Packaging
- 100mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- DC21536
- Product name
- PS210
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- DC21536
- Product name
- PS210
- Purity
- >98%
- Packaging
- 1g
- Price
- $2900
- Updated
- 2021/12/16
PS 210 Chemical Properties,Usage,Production
Uses
PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].
References
[1] Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. DOI:10.1016/j.chembiol.2012.07.017
[2] Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. DOI:10.1073/pnas.1415365112
PS 210 Preparation Products And Raw materials
Raw materials
Preparation Products
PS 210 Suppliers
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2989
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12476
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58