PS 210

Product Name: PS 210
CAS No.: 1221962-86-2
Chemical Name: PS 210
Synonyms: PS 210;PS210 ，S3462;PS210, 10 mM in DMSO;2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid;2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid;2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid;Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-;pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit
CBNumber: CB85867297
Molecular Formula: C19H15F3O5
Formula Weight: 380.31
MOL File: 1221962-86-2.mol

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PS 210 Property

Boiling point:: 577.9±50.0 °C(Predicted)
Density: 1.400±0.06 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);262.94(Max Conc. mM)
form: A crystalline solid
pka: 2.93±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 250mg
Price: $1450
Updated: 2021/12/16

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 1g
Price: $2900
Updated: 2021/12/16

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PS 210 Chemical Properties,Usage,Production

Uses

PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].

References

[1] Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. DOI:10.1016/j.chembiol.2012.07.017
[2] Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. DOI:10.1073/pnas.1415365112

PS 210 Preparation Products And Raw materials

Raw materials

Preparation Products

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PS 210 Suppliers

China 70 United States 3 Global 73

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2985
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9955
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30227
Advantage: 58

1221962-86-2, PS 210Related Search:

PS 210

2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid

Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-

2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid

pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit

PS210, 10 mM in DMSO

2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid

PS210 ，S3462

1221962-86-2