ChemicalBook > CAS DataBase List > Calcipotriol Monohydrate

Calcipotriol Monohydrate

Product Name: Calcipotriol Monohydrate
CAS No.: 147657-22-5
Chemical Name: Calcipotriol Monohydrate
Synonyms: Calcipotriol monohydrate CRS;Calcipotriol m;Carbotriol monohydrate;CALCIPOTRIOL MONOHYDRATE;Calcipotriol monohydrate 98%;Calcipotriol monohydrate - Bio-X ?;Calcipotriol monohydrate, 10 mM in DMSO;Calcipotriol (Calcipotriene) Monohydrate;(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol;(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
CBNumber: CB8588339
Molecular Formula: C27H42O4
Formula Weight: 430.63
MOL File: 147657-22-5.mol

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Calcipotriol Monohydrate Property

storage temp.: 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form: Powder
color: White to off-white
Stability:: Hygroscopic, Light sensitive
InChIKey: XBKHACNRWFKJNC-IZXATKCONA-N
SMILES: C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P322Specific measures (see …on this label).

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Packaging: 500mg
Price: $2505
Updated: 2024/03/01

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Packaging: 50mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Packaging: 100mg
Price: $575
Updated: 2024/03/01

TRC

Product number: C144230
Product name: CalcipotriolMonohydrate
Packaging: 25mg
Price: $825
Updated: 2021/12/16

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Calcipotriol Monohydrate Chemical Properties,Usage,Production

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D₃). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Calcipotriol monohydrate is a synthetic vitamin D3 analog with high affinity for the vitamin D receptor. It is used alone or in combination with betamethasone dipropionate for the treatment of psoriasis.

Definition

ChEBI: Calcipotriol hydrate is a hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as an antipsoriatic. It contains a calcipotriol.

in vivo

One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model)^[3].

References

[1] KRAGBALLE K. Vitamin D analogues in the treatment of psoriasis[J]. Journal of cellular biochemistry, 1992, 49 1: 46-52. DOI: 10.1002/jcb.240490109
[2] C. JOHANSEN. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin[J]. British Journal of Dermatology, 2004, 151 3: 600-607. DOI: 10.1111/j.1365-2133.2004.06088.x
[3] MEI LI. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.[J]. ACS Catalysis , 2006: 11736-11741. DOI: 10.1073/pnas.0604575103

Calcipotriol Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Calcipotriol Monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Calcipotriol Monohydrate 147657-22-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97.5%
Supply Ability: 50g
Release date: 2025-11-19

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Calcipotriol Monohydrate 147657-22-5
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 95.5%
Supply Ability: 10000
Release date: 2024-11-08

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Calcipotriol 147657-22-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-11-15

147657-22-5, Calcipotriol MonohydrateRelated Search:

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one Carboplatin CALCIUM THIOGLYCOLATE TRIHYDRATE Calcipotriene Calcipotriene

CALCIPOTRIOL MONOHYDRATE

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate

(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate

1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-

Calcipotriol (Calcipotriene) Monohydrate

Calcipotriol monohydrate CRS

(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate

Calcipotriol monohydrate, 10 mM in DMSO

Carbotriol monohydrate

Calcipotriol monohydrate - Bio-X ?

Calcipotriol m

Calcipotriol monohydrate 98%

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-Cyclopropyl-4-hydroxy-1-methylbut-2-en-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]-ethylidene]-4-methylene-1,3-cyclohexanediol hydrate

147657-22-5

C27H40O3H2O

API

API intermediates