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Calcipotriol Monohydrate

Product Name
Calcipotriol Monohydrate
CAS No.
147657-22-5
Chemical Name
Calcipotriol Monohydrate
Synonyms
Calcipotriol monohydrate CRS;CALCIPOTRIOL MONOHYDRATE;Calcipotriol (Calcipotriene) Monohydrate;(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol;(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate;1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-
CBNumber
CB8588339
Molecular Formula
C27H42O4
Formula Weight
430.63
MOL File
147657-22-5.mol
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Calcipotriol Monohydrate Property

storage temp. 
4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility 
Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form 
Powder
color 
White to off-white
Stability:
Hygroscopic, Light sensitive
InChIKey
XBKHACNRWFKJNC-IZXATKCONA-N
SMILES
C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P322Specific measures (see …on this label).

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
500mg
Price
$2505
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
50mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
100mg
Price
$575
Updated
2024/03/01
TRC
Product number
C144230
Product name
CalcipotriolMonohydrate
Packaging
25mg
Price
$825
Updated
2021/12/16
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Calcipotriol Monohydrate Chemical Properties,Usage,Production

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

Calcipotriol Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Calcipotriol Monohydrate Suppliers

LEO PHARMA A/S
Tel
--
Fax
--
Email
drug.safety@leo-pharma.com
Country
Denmark
ProdList
6
Advantage
58
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View Lastest Price from Calcipotriol Monohydrate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Calcipotriol Monohydrate 147657-22-5
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99%
Supply Ability
10000
Release date
2024-09-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Calcipotriol Monohydrate 147657-22-5
Price
US $0.00-0.00/g/Bag
Min. Order
1g
Purity
97.5%
Supply Ability
50g
Release date
2021-07-30
Henan Fengda Chemical Co., Ltd
Product
CALCIPOTRIOL MONOHYDRATE 147657-22-5
Price
US $6.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

147657-22-5, Calcipotriol MonohydrateRelated Search:


  • CALCIPOTRIOL MONOHYDRATE
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate
  • (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate
  • 1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-
  • Calcipotriol (Calcipotriene) Monohydrate
  • Calcipotriol monohydrate CRS
  • (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
  • 147657-22-5
  • C27H40O3H2O
  • API
  • API intermediates