DPTIP
- Product Name
- DPTIP
- CAS No.
- 351353-48-5
- Chemical Name
- DPTIP
- Synonyms
- DPTIP;DPTIP, 10 mM in DMSO;Phenol, 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-;2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol;2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im idazol-2-yl]phenol;extracellular,Inhibitor,exosome,DPTIP,Phospholipase,vesicles,inhibit,N-SMase
- CBNumber
- CB85985177
- Molecular Formula
- C21H18N2O3S
- Formula Weight
- 378.44
- MOL File
- 351353-48-5.mol
DPTIP Property
- Boiling point:
- 608.3±55.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.27±0.25(Predicted)
- form
- Solid
- color
- Off-white to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6903
- Product name
- DPTIP
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $185
- Updated
- 2021/12/16
- Product number
- BD171497
- Product name
- DPTIP
- Packaging
- 5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- BD171497
- Product name
- DPTIP
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 5386CE
- Product name
- 2,6-Dimethoxy-4-(5-phenyl-4-thiophen-2-yl-1H-imidazol-2-yl)-phenol
- Packaging
- 10mg
- Price
- $387
- Updated
- 2021/12/16
- Product number
- BD171497
- Product name
- DPTIP
- Packaging
- 25mg
- Price
- $575
- Updated
- 2021/12/16
DPTIP Chemical Properties,Usage,Production
Uses
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].
in vivo
DPTIP potently (10?mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release[1].
| Animal Model: | Mice[1]. |
| Dosage: | 10?mg/kg. |
| Administration: | IP 0.5?h prior to IL-1β striatal injection. |
| Result: | Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4?h after compound administration. The number of astrocyte-derived EVs was reduced by 51?±?13% 2?h post IL-1β administration. |
storage
Store at -20°C
References
[1] Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. DOI:10.1038/s41598-018-36144-2
[2] Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. DOI:10.1080/14756366.2020.1754814
DPTIP Preparation Products And Raw materials
Raw materials
Preparation Products
DPTIP Suppliers
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