JCN037
- Product Name
- JCN037
- CAS No.
- 2305154-31-6
- Chemical Name
- JCN037
- Synonyms
- JCN037;JCN037, 10 mM in DMSO;N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine;[1,4]Dioxino[2,3-g]quinazolin-4-amine, N-(3-bromo-2-fluorophenyl)-7,8-dihydro-;JCN037,Epidermal growth factor receptor,HER1,Inhibitor,JCN-037,JCN 037,inhibit,EGFR,JGK-037,ErbB-1,JGK037,JGK 037
- CBNumber
- CB86187891
- Molecular Formula
- C16H11BrFN3O2
- Formula Weight
- 376.18
- MOL File
- 2305154-31-6.mol
JCN037 Property
- Boiling point:
- 466.1±45.0 °C(Predicted)
- Density
- 1.669±0.06 g/cm3(Predicted)
- solubility
- DMSO:250.0(Max Conc. mg/mL);664.57(Max Conc. mM)
- pka
- 5.55±0.20(Predicted)
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0129398
- Product name
- JCN037
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0129398
- Product name
- JCN037
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-0129398
- Product name
- JCN037
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0129398
- Product name
- JCN037
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $1250
- Updated
- 2021/12/16
JCN037 Chemical Properties,Usage,Production
Uses
JCN037 (JGK037) is non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively[1].
in vivo
JCN037 (compound 5) exhibits low oral bioavailability due to a rapid hydroxylation of the fused 1,4-dioxane ring, suggesting first pass metabolism[1].
JCN037 (compound 5, 300 mg/kg, BID) treatment provides a significant survival benefit, whereby median survival increased by 47% from 37.5 days to 55 days with 5 treatment[1].
References
[1] Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.
JCN037 Preparation Products And Raw materials
Raw materials
Preparation Products
JCN037 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58