4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

ChemicalBook > CAS DataBase List > 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

Product Name: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
CAS No.: 749886-87-1
Chemical Name: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
Synonyms: JSH-23;CS-1344;JSH-23 HCL;JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II;NFκB Activation Inhibitor II, JSH-23;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
CBNumber: CB8649474
Molecular Formula: C16H20N2
Formula Weight: 240.34
MOL File: Mol file

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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Property

Melting point:: 104.4-105.0℃
Boiling point:: 418.7±40.0 °C(Predicted)
Density: 1.086±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL
pka: 5.99±0.11(Predicted)
form: solid
color: off-white to gray-pink

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-41-50/53
Safety Statements: 26-39-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2921.59.8090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: J4455
Product name: JSH-23
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $176
Updated: 2024/03/01

TCI Chemical

Product number: M2734
Product name: 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity: >98.0%(GC)
Packaging: 25mg
Price: $212
Updated: 2022/04/27

TCI Chemical

Product number: M2734
Product name: 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity: >98.0%(GC)
Packaging: 100mg
Price: $464
Updated: 2024/03/01

Cayman Chemical

Product number: 15036
Product name: JSH-23
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 15036
Product name: JSH-23
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties,Usage,Production

Uses

A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23

Uses

JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.

Uses

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Definition

ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.

General Description

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

Biological Activity

jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].

Biochem/physiol Actions

Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity

target

NF-κB

References

[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE manufacturers

Career Henan Chemical Co

Product: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

749886-87-1, 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINERelated Search:

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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

JSH-23

4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23

JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II

NF-κB Activation Inhibitor II

JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine

4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine

NFκB Activation Inhibitor II, JSH-23

JSH-23;JSH23;JSH 23

CS-1344

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine&gt

1,2-Benzenediamine, 4-methyl-N1-(3-phenylpropyl)-

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE USP/EP/BP

JSH-23 HCL

Nuclear factor-κB,Nuclear factor-kappaB,JSH-23,NF-κB,JSH23,JSH 23,Inhibitor,inhibit

JSH-23, 98%, an NF-κB inhibitor which inhibits NF-κB transcriptional activity

749886-87-1

Chemical Amines

Amines

Aromatics

Inhibitors