ChemicalBook > CAS DataBase List > 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

Product Name: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
CAS No.: 749886-87-1
Chemical Name: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
Synonyms: JSH-23;CS-1344;JSH-23 HCL;JSH-23 ，S7351;JSH-23;JSH23;JSH 23;JSH-23, 10 mM in DMSO;JSH-23/749886-87-1/98%;J4455-5MG JSH-23【J4455】;NF-κB Activation Inhibitor II;NFκB Activation Inhibitor II, JSH-23
CBNumber: CB8649474
Molecular Formula: C16H20N2
Formula Weight: 240.34
MOL File: Mol file

Less

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Property

Melting point:: 104.4-105.0℃
Boiling point:: 418.7±40.0 °C(Predicted)
Density: 1.086±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL
pka: 5.99±0.11(Predicted)
form: solid
color: off-white to gray-pink

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 22-41-50/53
Safety Statements: 26-39-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2921.59.8090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: J4455
Product name: JSH-23
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: 481408-M
Product name: NF-κB Activation Inhibitor II, JSH-23
Purity: The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation
Packaging: 1 unit
Price: $213
Updated: 2025/07/31

TCI Chemical

Product number: M2734
Product name: 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity: >98.0%(GC)
Packaging: 25mg
Price: $212
Updated: 2022/04/27

TCI Chemical

Product number: M2734
Product name: 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity: >98.0%(GC)
Packaging: 100mg
Price: $418
Updated: 2025/07/31

Cayman Chemical

Product number: 15036
Product name: JSH-23
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Less

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties,Usage,Production

Uses

A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23

Uses

JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.

Uses

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Definition

ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.

General Description

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

Biological Activity

jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].

Biochem/physiol Actions

Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity

target

NF-κB

References

[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Suppliers

Americas 1 Canada 1 China 132 Europe 1 India 2 Japan 1 United States 19 Global 157

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Shanghai Qinghang Chemical Co. Ltd.

Tel: 021-50840321, 18601625411
Fax: 021-50840321
Email: thomasleehz@hotmail.com
Country: China
ProdList: 216
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

YouCoChem (Beijing) Chemical Technology Co., Ltd.

Tel: 18800159827
Email: youcochem@163.com
Country: China
ProdList: 162
Advantage: 50

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1633
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Shanghai jingkang bioengineering co., ltd.

Tel: 021-54721350 13524668266
Fax: 021-5
Email: 2881505714@qq.com
Country: China
ProdList: 7872
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Birdo (Shanghai) Medical Technology Co., Ltd.

Tel: 021-58099077-8041 18601625411
Email: sales@birdotech.com
Country: China
ProdList: 9764
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: +86-13522808617
Email: omichem@126.com
Country: China
ProdList: 6413
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Less

View Lastest Price from 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE manufacturers

Career Henan Chemical Co

Product: 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

749886-87-1, 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINERelated Search:

Behentrimonium Chloride 2-Methylindole (S)-(+)-Benzyl glycidyl ether Isoprene Octadecyl methacrylate 2-METHYL-1,3-PROPANEDIOL BAY 11-7082 3-METHYLADENINE Bortezomib 1,9-Pyrazoloanthrone Regorafenib SB 203580

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

JSH-23

4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23

JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II

NF-κB Activation Inhibitor II

JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine

4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine

NFκB Activation Inhibitor II, JSH-23

JSH-23;JSH23;JSH 23

CS-1344

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine&gt

1,2-Benzenediamine, 4-methyl-N1-(3-phenylpropyl)-

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE USP/EP/BP

JSH-23 HCL

Nuclear factor-κB,Nuclear factor-kappaB,JSH-23,NF-κB,JSH23,JSH 23,Inhibitor,inhibit

JSH-23, 98%, an NF-κB inhibitor which inhibits NF-κB transcriptional activity

JSH 23, NFkappaB transcriptional activity inhibitor

JSH-23, 10 mM in DMSO

JSH-23/749886-87-1/98%

J4455-5MG JSH-23【J4455】

JSH-23 ，S7351

749886-87-1

Chemical Amines

Amines

Aromatics

Inhibitors