Antazoline
- Product Name
- Antazoline
- CAS No.
- 91-75-8
- Chemical Name
- Antazoline
- Synonyms
- 5512-M;Avissul;Azalone;Antastan;Antasten;Antistin;Antazolin;Antistine;Chemiopen;Histostab
- CBNumber
- CB8667315
- Molecular Formula
- C17H19N3
- Formula Weight
- 265.35
- MOL File
- 91-75-8.mol
Antazoline Property
- Melting point:
- 120-122°
- Boiling point:
- 398.57°C (rough estimate)
- Density
- 0.9786 (rough estimate)
- refractive index
- 1.6080 (estimate)
- pka
- pKa 6.65(H2O t = 25 I = 0.05) (Uncertain)
- form
- A solid
- color
- White to off-white
- Water Solubility
- 663.4mg/L(30 ºC)
- CAS DataBase Reference
- 91-75-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Antazoline(91-75-8)
Safety
- Hazardous Substances Data
- 91-75-8(Hazardous Substances Data)
- Toxicity
- LD50 oral in mouse: 398mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FA30098
- Product name
- Antazoline
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- G399
- Product name
- Antazoline
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FA30098
- Product name
- Antazoline
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA30098
- Product name
- Antazoline
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- API0007303
- Product name
- ANTAZOLINE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $225.75
- Updated
- 2021/12/16
Antazoline Chemical Properties,Usage,Production
Chemical Properties
White, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether.
Originator
Antistine HCl,Ciba,US,1948
Uses
Antihistaminic.
Definition
ChEBI: A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Manufacturing Process
15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Therapeutic Function
Antihistaminic
Clinical Use
Antazoline is used for local application to the eye in allergic conjunctivitis.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.
Antazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Antazoline manufacturers
- Product
- Antazoline 91-75-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-11
- Product
- Antazoline 91-75-8
- Price
- US $13.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 200ton
- Release date
- 2024-06-19
- Product
- Antazoline 91-75-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-07-22