ChemicalBook > CAS DataBase List > BOC-DL-PHE-OH

BOC-DL-PHE-OH

Product Name: BOC-DL-PHE-OH
CAS No.: 4530-18-1
Chemical Name: BOC-DL-PHE-OH
Synonyms: BOC-DL-PHE-OH;Boc-N-Me-D-Phe;Boc-N-Me-Phe-OH;BOC-DL-PHENYLALANINE;BOC-DL-PHE-OH USP/EP/BP;N-Boc-DL-phenylalanine,95%;N-Boc-DL-phenylalanine, 95%;N-Methyl-Boc-D-phenylalanine;(Tert-Butoxy)Carbonyl DL-Phe-OH;Boc-DL-phenylalanine≥ 99% (HPLC)
CBNumber: CB8676270
Molecular Formula: C14H19NO4
Formula Weight: 265.3
MOL File: 4530-18-1.mol

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BOC-DL-PHE-OH Property

Melting point:: 106-108 °C
Boiling point:: 426.6±38.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.88±0.10(Predicted)
form: Solid
color: White to off-white
CAS DataBase Reference: 4530-18-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6486
Product name: Boc-DL-Phe-OH
Packaging: 25G
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: B6486
Product name: Boc-DL-Phe-OH
Packaging: 100G
Price: $178
Updated: 2025/07/31

AK Scientific

Product number: 0312AP
Product name: Boc-DL-Phe-OH
Packaging: 5g
Price: $17
Updated: 2021/12/16

Activate Scientific

Product number: AS91734
Product name: N-Boc-DL-Phenylalanine
Purity: 95+%
Packaging: 5G
Price: $35
Updated: 2021/12/16

Chem-Impex

Product number: 04010
Product name: Boc-DL-phenylalanine,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 5G
Price: $40.54
Updated: 2021/12/16

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BOC-DL-PHE-OH Chemical Properties,Usage,Production

Uses

2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid is a phenylalanine derivative[1].

Synthesis

150-30-1

24424-99-5

4530-18-1

General procedure for the synthesis of 2-((tert-butoxycarbonyl)amino)-3-phenylpropionic acid from DL-phenylalanine and di-tert-butyl dicarbonate: DL-phenylalanine (1 g, 6.05 mmol) was suspended in a mixture of dioxane (15 mL) and NaOH (2M aqueous solution; 3.63 mL, 7.26 mmol) at 0 °C. Subsequently, di-tert-butyl dicarbonate (1.546 mL, 6.66 mmol) was added slowly and dropwise to this suspension. The reaction mixture was stirred continuously for 5 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. Water (30 mL) was added to the concentrate and the pH of the mixture was adjusted to 3 by dropwise addition of cold 1.5 N HCl solution.The aqueous layer was extracted with ethyl acetate (3 x 50 mL) and the organic layers were combined and washed with brine solution (2 x 50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated to afford the target product 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid (1.3 g, 4.90 mmol, 81% yield) as a gelatinous liquid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 12.6 (br-s, 1H), 7.32-7.26 (m, 5H), 7.10-6.95 (br-s, 1H), 4.12-4.00 (m, 1H), 3.05-2.92 (m, 1H), 2.87- 2.75 (m, 1H), 1.31 (s, 9H); MS (ESI) m/z 266.2 [M+H]+.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-882. DOI:10.1080/10408398.2012.708368

BOC-DL-PHE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-DL-PHE-OH Suppliers

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View Lastest Price from BOC-DL-PHE-OH manufacturers

Career Henan Chemical Co

Product: BOC-DL-PHE-OH 4530-18-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

4530-18-1, BOC-DL-PHE-OHRelated Search:

BOC-DL-PRO-OH BOC-DL-LEU-OH H2O Boc-D-isoleucine Boc-DL-alanine BOC-D-LYS(Z)-OH N-Boc-N'-Fmoc-D-lysine BOC-D-MEPHE-OH DCHA BOC-D-LEUCINOL BOC-D-LEUCINE METHYL ESTER BOC-D-LEU-OSU

BOC-DL-PHENYLALANINE

BOC-DL-PHE-OH

N-ALPHA-T-BUTOXYCARBONYL-D-PHENYLALANINE

N-tert-Butoxycarbonyl-DL-phenylalanine

N-Methyl-Boc-D-phenylalanine

Boc-N-Me-Phe-OH

BOC-DL-Phenylalanine(Boc-DL-Phe-OH)

2-(tert-butoxycarbonyl(Methyl)aMino)-3-phenylpropanoic acid

N-Boc-DL-phenylalanine, 95%

Boc-N-Me-D-Phe

Boc-DL-phenylalanine≥ 99% (HPLC)

(Tert-Butoxy)Carbonyl DL-Phe-OH

Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

N-Boc-DL-phenylalanine,95%

BOC-DL-PHE-OH USP/EP/BP

2-(tert-Butoxycarbonylamino)-3-phenylpropanoic acid (Bortezomib Impurity)

4530-18-1

Phenylalanine [Phe, F]