CIRAZOLINE HYDROCHLORIDE

Product Name: CIRAZOLINE HYDROCHLORIDE
CAS No.: 40600-13-3
Chemical Name: CIRAZOLINE HYDROCHLORIDE
Synonyms: LD-3098;Cirazoline hydrochlo;LD 3098 hydrochloride;CIRAZOLINE HYDROCHLORIDE;CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE;2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE;2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride;2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
CBNumber: CB8676982
Molecular Formula: C13H17ClN2O
Formula Weight: 252.74
MOL File: 40600-13-3.mol

More

Less

CIRAZOLINE HYDROCHLORIDE Property

storage temp.: Store at RT
solubility: H₂O: >35 mg/mL
form: solid
color: white

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C223
Product name: Cirazoline hydrochloride
Purity: solid
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $296
Updated: 2024/03/01

TRC

Product number: C497403
Product name: Cirazoline hydrochloride
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

More

Less

CIRAZOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Cirazoline is an α₁-adrenergic receptor (α₁-AR) agonist (K_is = 120, 960, and 660 nM for recombinant α_1A-, α_1B-, and α_1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α_1A- and a partial agonist at α_1B- and α_1D-ARs in vitro (EC₅₀s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α₂-ARs with a pA₂ value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.

Uses

Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.

Biological Activity

Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .

Biochem/physiol Actions

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.

storage

Store at RT

CIRAZOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CIRAZOLINE HYDROCHLORIDE Suppliers

China 21 Europe 1 Germany 2 India 1 South Korea 1 Switzerland 1 United Kingdom 2 United States 8 Global 37

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7266
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

40600-13-3, CIRAZOLINE HYDROCHLORIDERelated Search:

IMIDAZOLE HYDROCHLORIDE Fenoxazoline 2-(2-ISOPROPYLPHENOXY)ETHYLAMINE CIRAZOLINE HYDROCHLORIDE 2-CYCLOPROPYLPHENOL CIRAZOLINE HYDROCHLORIDE CHEMBRDG-BB 9070607 FENOXAZOLINE HYDROCHLORIDE SALOR-INT L168610-1EA CYCLOPROPYLBENZENE

2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride

CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE

CIRAZOLINE HYDROCHLORIDE

2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE

2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE

LD-3098

LD 3098 hydrochloride

Cirazoline hydrochlo

40600-13-3

Adrenoceptor