CIRAZOLINE HYDROCHLORIDE

Product Name: CIRAZOLINE HYDROCHLORIDE
CAS No.: 40600-13-3
Chemical Name: CIRAZOLINE HYDROCHLORIDE
Synonyms: LD-3098;Cirazoline hydrochlo;LD 3098 hydrochloride;CIRAZOLINE HYDROCHLORIDE;CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE;2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE;2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride;2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
CBNumber: CB8676982
Molecular Formula: C13H17ClN2O
Formula Weight: 252.74
MOL File: 40600-13-3.mol

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CIRAZOLINE HYDROCHLORIDE Property

storage temp.: Store at RT
solubility: H₂O: >35 mg/mL
form: solid
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C223
Product name: Cirazoline hydrochloride
Purity: solid
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 21791
Product name: Cirazoline (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $296
Updated: 2024/03/01

TRC

Product number: C497403
Product name: Cirazoline hydrochloride
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

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CIRAZOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Cirazoline is an α₁-adrenergic receptor (α₁-AR) agonist (K_is = 120, 960, and 660 nM for recombinant α_1A-, α_1B-, and α_1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α_1A- and a partial agonist at α_1B- and α_1D-ARs in vitro (EC₅₀s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α₂-ARs with a pA₂ value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.

Uses

Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.

Biological Activity

Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .

Biochem/physiol Actions

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.

storage

Store at RT

CIRAZOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CIRAZOLINE HYDROCHLORIDE Suppliers

China 21 Europe 1 Germany 2 India 1 South Korea 1 Switzerland 1 United Kingdom 2 United States 7 Global 36

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40600-13-3, CIRAZOLINE HYDROCHLORIDERelated Search:

IMIDAZOLE HYDROCHLORIDE Fenoxazoline 2-(2-ISOPROPYLPHENOXY)ETHYLAMINE CIRAZOLINE HYDROCHLORIDE 2-CYCLOPROPYLPHENOL CIRAZOLINE HYDROCHLORIDE CHEMBRDG-BB 9070607 FENOXAZOLINE HYDROCHLORIDE SALOR-INT L168610-1EA CYCLOPROPYLBENZENE

2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride

CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE

CIRAZOLINE HYDROCHLORIDE

2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE

2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE

LD-3098

LD 3098 hydrochloride

Cirazoline hydrochlo

40600-13-3

Adrenoceptor