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4-formyl-3-methoxybenzonitrile

Product Name
4-formyl-3-methoxybenzonitrile
CAS No.
21962-45-8
Chemical Name
4-formyl-3-methoxybenzonitrile
Synonyms
4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;Finerenone Impurity 111;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;Para-tert-Butyl Benzene Sulfonamide
CBNumber
CB8684633
Molecular Formula
C9H7NO2
Formula Weight
161.16
MOL File
21962-45-8.mol
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4-formyl-3-methoxybenzonitrile Property

Melting point:
109-111℃
Boiling point:
318℃
Density 
1.18
vapor pressure 
0.003-2.3Pa at 20-80℃
Flash point:
138℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
InChI
InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
InChIKey
ZXENVSJZOHXCKL-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(C=O)C(OC)=C1
LogP
1.42 at 20℃ and pH7
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C998488
Product name
4-Cyano-2-methoxybenzaldehyde
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J98031
Product name
4-Cyano-2-methoxybenzaldehyde
Packaging
5g
Price
$90
Updated
2021/12/16
AK Scientific
Product number
X2725
Product name
4-Cyano-2-methoxybenzaldehyde
Packaging
25g
Price
$374
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0150549
Product name
4-CYANO-2-METHOXYBENZALDEHYDE
Purity
95.00%
Packaging
5MG
Price
$500.81
Updated
2021/12/16
AHH
Product number
MT-07065
Product name
4-Cyaon-2-methoxybenzaldehyde
Purity
98%
Packaging
25g
Price
$518
Updated
2021/12/16
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4-formyl-3-methoxybenzonitrile Chemical Properties,Usage,Production

Uses

4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.

Synthesis

79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.

4-formyl-3-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-formyl-3-methoxybenzonitrile Suppliers

Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 13327700685
Email
sales@vcarepharmatech.com
Country
China
ProdList
508
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Changzhou Ansciep Chemical Co., Ltd.
Tel
0519-86305871 2719466718
Email
tina@ansciepchem.com
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China
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1834
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58
Shanghai Qitong Pharmaceutical Technology Co., Ltd.
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18918399319 18918399319
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24907461@qq.com
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China
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58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
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0571-86828652 18857119830
Fax
0571-83522824
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sales@chemtrue-bio.com
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China
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Jinan XinKe Pharmaceutical Technology Co., Ltd.
Tel
0531-88259693 17854196142
Fax
0531-88259693
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2820602043@qq.com
Country
China
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Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
276
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Jinan Guoding Pharmaceutical Technology Co., Ltd.
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15665775653
Fax
053167801621
Email
sales@guodingpharma.com
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China
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YANGZHOU HENGCHUAN CHEMICAL CO., LTD.
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13775575144 13775575144
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59033115@qq.com
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China
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PureChemland Co.,Ltd.
Tel
028-64441822 18581895003
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3848291069@qq.com
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China
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3337
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Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
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View Lastest Price from 4-formyl-3-methoxybenzonitrile manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
4-CYANO-2-METHOXYBENZALDEHYDE 21962-45-8
Price
US $1.00/g
Min. Order
1g
Purity
99.0
Supply Ability
2000
Release date
2023-11-06
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
4-Cyano-2-methoxybenzaldehyde 21962-45-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-01-05
Cangzhou Kangrui Pharma Tech Co. Ltd.,
Product
4-Cyano-2-methoxybenzaldehyde 21962-45-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
150kgs
Release date
2024-12-02

21962-45-8, 4-formyl-3-methoxybenzonitrileRelated Search:


  • 4-CYANO-2-METHOXYBENZALDEHYDE
  • 4-Cyaon-2-methoxybenzaldehyde
  • 2-Methoxy-4-cyanobenzaldehyde
  • 4-forMyl-3-Methoxybenzonitrile
  • 4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)
  • Benzonitrile, 4-formyl-3-methoxy-
  • 4-Formyl-3-methoxybenzonitrile (or) 4-Cyano-2-Methoxy Benzaldehyde
  • 4-Cyano-2-neneneba methoxy Benzaldehyde
  • 4-Cyan0-2-methoxybenzaldehyde
  • 4-CYANO-2-METHOXYBENZALDEHYDE,Finerenone
  • 3-Formyl-3-methoxybenzonitrile
  • 4-Formyl-3-methoxybenzonitril
  • Finerenone Impurity 111
  • Para-tert-Butyl Benzene Sulfonamide
  • 21962-45-8
  • Intermediate
  • 21962-45-8