2-AG-D8
- Product Name
- 2-AG-D8
- CAS No.
- 924894-97-3
- Chemical Name
- 2-AG-D8
- Synonyms
- 2-AG-D8;NOLADIN-D8;2-ARACHIDONOYL GLYCEROL-D8;RCRCTBLIHCHWDZ-FBFLGLDDSA-N;5Z,8Z,11Z,14Z-EICOSATETRAENOIC-5,6,8,9,11,12,14,15-D8 ACID, 2-GLYCERYL ESTER
- CBNumber
- CB8685236
- Molecular Formula
- C23H30D8O4
- Formula Weight
- 386.59
- MOL File
- Mol file
2-AG-D8 Property
- solubility
- DMSO: 10 mg/ml; Ethanol: Miscible; PBS (7.2): ~150 μg/ml
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 362160
- Product name
- 2-Arachidonoyl Glycerol-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 25μg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 362160
- Product name
- 2-Arachidonoyl Glycerol-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 50μg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- 362160
- Product name
- 2-Arachidonoyl Glycerol-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 100μg
- Price
- $265
- Updated
- 2024/03/01
- Product number
- 362160
- Product name
- 2-Arachidonoyl Glycerol-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 500μg
- Price
- $1102
- Updated
- 2024/03/01
- Product number
- BAR0001832
- Product name
- 2-ARACHIDONOYL GLYCEROL-D8
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.28
- Updated
- 2021/12/16
2-AG-D8 Chemical Properties,Usage,Production
Description
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.
Uses
2-Arachidonoylglycerol-d8 is the deuterium labeled 2-Arachidonoylglycerol. 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system.
Definition
ChEBI: 2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol. It has a role as a human metabolite. It is an endocannabinoid and a 2-acylglycerol 20:4. It is functionally related to an arachidonic acid.
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Stella N, et al. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997 Aug 21;388(6644):773-8. DOI:10.1038/42015
2-AG-D8 Preparation Products And Raw materials
Raw materials
Preparation Products
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