METHYLTRIPHENOXYPHOSPHONIUM IODIDE Property

Melting point:

142-146 °C(lit.)

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Sparingly)

form 

solid

color 

Dark Orange to Very Dark Brown

BRN 

3580189

Stability:

Hygroscopic, Moisture Sensitive

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-8-10

HS Code 

29310099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

METHYLTRIPHENOXYPHOSPHONIUM IODIDE Chemical Properties,Usage,Production

Chemical Properties

Yellow-Brownish Solid

Uses

Methyltriphenoxyphosphonium Iodide is used in the transformation of the 5’-hydroxyl group in nucleosides to the 5’-deoxy-5’-iodo group.

Uses

Used in the transformation of the 5′-hydroxyl group in nucleosides to the 5′-deoxy-5′-iodo group.

Uses

Methyltriphenoxyphosphonium Iodide is used in the transformation of the 5?hydroxyl group in nucleosides to the 5?deoxy-5?iodo group

Purification Methods

Gently heat the impure iodide with good grade Me2CO. The saturated solution obtained is decanted rapidly from undissolved salt and treated with an equal volume of dry Et2O. The iodide separates as flat needles which are collected by centrifugation, washed several times with dry Et2O, and dried in a vacuum over P2O5. For this recrystallisation it is essential to minimise the time of contact with Me2CO and to work rapidly and with rigorous exclusion of moisture. If the crude material is to be used, it should be stored under dry Et2O, and dried and weighed in vacuo immediately before use. [Landauer & Rydon J Chem Soc 224 1953, Hudson et al. J Chem Soc Perkin Trans 1 982 1974, Beilstein 6 IV 704.]