ChemicalBook > CAS DataBase List > 3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE

3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE

Product Name
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
CAS No.
185259-85-2
Chemical Name
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
Synonyms
GR 46611;GR 46611, 5-HT1B/1D agonist;3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE;3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide;2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-
CBNumber
CB8690764
Molecular Formula
C23H27N3O2
Formula Weight
377.48
MOL File
185259-85-2.mol
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3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE Property

Boiling point:
645.9±55.0 °C(Predicted)
Density 
1.168
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
pka
14.51±0.46(Predicted)
form 
solid
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris
Product number
0864
Product name
GR46611
Packaging
10
Price
$130
Updated
2021/12/16
Tocris
Product number
0864
Product name
GR46611
Packaging
50
Price
$544
Updated
2021/12/16
TRC
Product number
G779553
Product name
GR46611
Packaging
10mg
Price
$180
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008779
Product name
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
Purity
95.00%
Packaging
10MG
Price
$702.19
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008779
Product name
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
Purity
95.00%
Packaging
50MG
Price
$1199.42
Updated
2021/12/16
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3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE Chemical Properties,Usage,Production

Uses

GR 46611is a 5-HT1D agonist.

Definition

ChEBI: 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide is a member of tryptamines.

Biological Activity

5-HT 1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT 1D receptor ligands.

in vivo

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4].

Animal Model:Dravet syndrome (DS) mice[1]
Dosage:0.01, 0.1 and 1 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Improved survival relative to vehicle treated controls with 89% surviving rate.

IC 50

5-HT1D Receptor

3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE Suppliers

China 33 Germany 1 Switzerland 2 United Kingdom 3 United States 10 Global 49
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185259-85-2, 3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDERelated Search:

5-METHYL-N,N-DIMETHYLTRYPTAMINE 3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE

  • 3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
  • GR 46611
  • 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide
  • 2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-
  • GR 46611, 5-HT1B/1D agonist
  • 185259-85-2