ChemicalBook > CAS DataBase List > 4,6-Dimethylpyrimidine-5-carboxylic acid

4,6-Dimethylpyrimidine-5-carboxylic acid

Product Name: 4,6-Dimethylpyrimidine-5-carboxylic acid
CAS No.: 157335-93-8
Chemical Name: 4,6-Dimethylpyrimidine-5-carboxylic acid
Synonyms: 5-Carboxy-4,6-dimethylpyrimidine;4,6-Dimethylpyrimidine-5-carboxylicaci;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID;4,6-dimethyl 5-pyrimidine carboxylic acid;5-PyriMidinecarboxylicacid, 4,6-diMethyl-;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID ,98%;5-Pyrimidinecarboxylicacid,4,6-dimethyl-(9CI);4,6-dimethylpyrimidine-5-carboxylic acid - [D20471];4,6-Dimethylpyrimidine-5-carboxylic acid ISO 9001：2015 REACH;5-Carboxy-4,6-dimethylpyrimidine, 5-Carboxy-4,6-dimethyl-1,3-diazine
CBNumber: CB8691352
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 157335-93-8.mol

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4,6-Dimethylpyrimidine-5-carboxylic acid Property

Boiling point:: 319.7±37.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.78±0.32(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 157335-93-8(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D460055
Product name: 4,6-Dimethylpyrimidine-5-carboxylicAcid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR5844
Product name: 4,6-Dimethylpyrimidine-5-carboxylicacid
Packaging: 250mg
Price: $29
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-Q3
Product name: 4,6-Dimethylpyrimidine-5-carboxylic acid
Packaging: 250mg
Price: $32
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD11922
Product name: 4,6-Dimethylpyrimidine-5-carboxylic acid
Packaging: 250mg
Price: $52.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD11922
Product name: 4,6-Dimethylpyrimidine-5-carboxylic acid
Packaging: 500mg
Price: $85
Updated: 2021/12/16

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4,6-Dimethylpyrimidine-5-carboxylic acid Chemical Properties,Usage,Production

Uses

4,6-Dimethylpyrimidine-5-carboxylic acid is a pharmaceutical intermediate compound used in the preparation of macrocyclic broad-spectrum antibiotics.

Synthesis

305794-79-0

157335-93-8

Ethyl 4,6-dimethylpyrimidine-5-carboxylate (10.9 g, 0.0605 mol) was used as starting material, which was mixed with an aqueous solution (70 mL) of sodium hydroxide (4.0 g, 0.10 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was acidified with concentrated hydrochloric acid and subsequently the solution was concentrated to dryness. To the dried residue, acetone (100 mL) was added, the insoluble sodium chloride was removed by filtration, and the solid was washed with methanol (100 mL). The filtrate was concentrated to dryness and the resulting residue was washed with acetonitrile (ACN) to give a final 8.5 g (92% yield) of 4,6-dimethylpyrimidine-5-carboxylic acid solid product. The mass spectrum (EI) showed a m/z of 153.1 (M + 1). 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.89 (s, 1H), 2.56 (s, 6H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 709 - 712
[2] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 1220
[3] Patent: US6391865, 2002, B1. Location in patent: Page column 86
[4] Patent: EP1175402, 2005, B1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 567 - 571

4,6-Dimethylpyrimidine-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Heptane Potassium tert-butoxide Copper(II) acetate tert-Butyl methyl ether Acetone Formamidine acetate Sodium chloride Toluene Methyl acetoacetate Trimethyl orthoacetate Tetrahydrofuran Sodium citrate Hydrochloric acid Methanol Sodium hydroxide

Preparation Products

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View Lastest Price from 4,6-Dimethylpyrimidine-5-carboxylic acid manufacturers

Dideu Industries Group Limited

Product: 4,6-Dimethylpyrimidine-5-carboxylic acid 157335-93-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-06

Career Henan Chemical Co

Product: 4,6-Dimethylpyrimidine-5-carboxylic acid 157335-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-09

157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acidRelated Search:

2,6-Lutidine 4,6-Dichloropyrimidine Fluorocytosine 2,5-Dimethylpyridine 3,5-Dimethylbenzoic acid 4,6-Dihydroxypyrimidine 2,6-Dimethylphenol 4-Ethyl-5-fluoro-6-hydroxypyrimidine Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate ETHYL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYLMETHYLSULFONAMIDO)PYRIMIDINE-5-CARBOXYLATE-D6 5-Pyrimidinecarboxylic acid 4,6-DIMETHYLPYRIMIDINE Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-amino-pyrimidine-5-carboxylate METHYL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(METHYLSULFONYL)PYRIMIDINE-5-CARBOXYLATE-D6 Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylsulfonamido)pyrimidine-5-carboxylate

4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID

5-Pyrimidinecarboxylicacid,4,6-dimethyl-(9CI)

4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID ,98%

5-Carboxy-4,6-dimethylpyrimidine

5-PyriMidinecarboxylicacid, 4,6-diMethyl-

5-Carboxy-4,6-dimethylpyrimidine, 5-Carboxy-4,6-dimethyl-1,3-diazine

4,6-dimethyl 5-pyrimidine carboxylic acid

4,6-Dimethylpyrimidine-5-carboxylicaci

4,6-Dimethylpyrimidine-5-carboxylic acid ISO 9001：2015 REACH

4,6-dimethylpyrimidine-5-carboxylic acid - [D20471]

157335-93-8

Pyrimidine

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

Boronic Acid

Heterocyclic Compounds

Pyrimidines

pharmacetical

CARBOXYLICACID

Heterocycle-Pyrimidine series

Heterocycles