PYR-GLU-PRO-NH2

Product Name: PYR-GLU-PRO-NH2
CAS No.: 85541-78-2
Chemical Name: PYR-GLU-PRO-NH2
Synonyms: FPP;PE-E-P-NH2;(GLU2)-TRH;GLP-GLU-PRO-NH2;PYR-GLU-PRO-NH2;pGlu-Glu-Pro-NH2;PGLU-GLU-PRO AMIDE;PYROGLU-GLU-PRO AMIDE;(Glu2)-TRH Pyr-Glu-Pro-NH2;GLP-GLU-PRO-NH2: GLP-EP-NH2
CBNumber: CB8695921
Molecular Formula: C15H22N4O6
Formula Weight: 354.36
MOL File: 85541-78-2.mol

More

Less

PYR-GLU-PRO-NH2 Property

Boiling point:: 899.9±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: −20°C
form: Solid
pka: 4.47±0.10(Predicted)
color: White to off-white

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0004293
Product name: PGLU-GLU-PRO AMIDE
Purity: 95.00%
Packaging: 5MG
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004293
Product name: PGLU-GLU-PRO AMIDE
Purity: 95.00%
Packaging: 25MG
Price: $1020.53
Updated: 2021/12/16

More

Less

PYR-GLU-PRO-NH2 Chemical Properties,Usage,Production

Uses

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].

Definition

ChEBI: Pglu-glu-pro-amide is an oligopeptide.

in vivo

(Glu2)-TRH (1-100 μmol/kg; IV) dose-dependently attenuated TRH-induced analeptic action^[1].
(Glu2)-TRH (10 μmol/kg; IV) 10 min before Pentobarbital (60 mg/kg; i.p.) decreases the sleeping time by approximately 20% compared to the vehicle treated group^[1].

Animal Model:	Male Swiss-Webster mice (30 g)^[1]
Dosage:	1, 2, 5, 10, 15, 25, 50, 100 μmol/kg
Administration:	IV; 10 min before Pentobarbital (60 mg/kg, i.p.)
Result:	Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.

References

[1] Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6. DOI:10.1016/j.brainresbull.2010.02.007

PYR-GLU-PRO-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PYR-GLU-PRO-NH2 Suppliers

China 66 Germany 1 Switzerland 1 United Kingdom 1 United States 7 Global 76

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

85541-78-2, PYR-GLU-PRO-NH2Related Search:

thyrotropin-releasing hormone, 1-Me- TRH-GLY TRH PYR-HIS-PRO-BETANA PYR-HIS-PRO-AMC Thyrotropin-releasing hormone TRH 5-OXO-5-PYRROLIDIN-1-YL-PENTANOIC ACID PYR-GLU-PRO-NH2

pyroglutamyl-glutamyl-prolineamide

fertilization promoting peptide

GLP-GLU-PRO-NH2: GLP-EP-NH2

pGlu-Glu-Pro-NH2

PYR-GLU-PRO-NH2

PYROGLU-GLU-PRO AMIDE

PGLU-GLU-PRO AMIDE

PE-E-P-NH2

FPP, Fertilization-ProMoting Peptide

FPP

GLP-GLU-PRO-NH2

(GLU2)-THYROTROPIN-RELEASING HORMONE

(GLU2)-TRH

L-Prolinamide, 5-oxo-L-prolyl-L-α-glutamyl-

(Glu2)-TRH Pyr-Glu-Pro-NH2

5-Oxo-L-prolyl-L-α-glutamyl-L-prolinamide

(S)-5-((S)-2-Carbamoylpyrrolidin-1-yl)-5-oxo-4-((S)-5-oxopyrrolidine-2-carboxamido)pentanoic acid

85541-78-2

C15H22N4O6

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

TRH

Releasing Factors