PYR-GLU-PRO-NH2

Product Name: PYR-GLU-PRO-NH2
CAS No.: 85541-78-2
Chemical Name: PYR-GLU-PRO-NH2
Synonyms: FPP;PE-E-P-NH2;(GLU2)-TRH;GLP-GLU-PRO-NH2;PYR-GLU-PRO-NH2;pGlu-Glu-Pro-NH2;PGLU-GLU-PRO AMIDE;PYROGLU-GLU-PRO AMIDE;(Glu2)-TRH Pyr-Glu-Pro-NH2;GLP-GLU-PRO-NH2: GLP-EP-NH2
CBNumber: CB8695921
Molecular Formula: C15H22N4O6
Formula Weight: 354.36
MOL File: 85541-78-2.mol

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PYR-GLU-PRO-NH2 Property

Boiling point:: 899.9±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: −20°C
form: Solid
pka: 4.47±0.10(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0004293
Product name: PGLU-GLU-PRO AMIDE
Purity: 95.00%
Packaging: 5MG
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004293
Product name: PGLU-GLU-PRO AMIDE
Purity: 95.00%
Packaging: 25MG
Price: $1020.53
Updated: 2021/12/16

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PYR-GLU-PRO-NH2 Chemical Properties,Usage,Production

Uses

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].

Definition

ChEBI: Pglu-glu-pro-amide is an oligopeptide.

in vivo

(Glu2)-TRH (1-100 μmol/kg; IV) dose-dependently attenuated TRH-induced analeptic action^[1].
(Glu2)-TRH (10 μmol/kg; IV) 10 min before Pentobarbital (60 mg/kg; i.p.) decreases the sleeping time by approximately 20% compared to the vehicle treated group^[1].

Animal Model:	Male Swiss-Webster mice (30 g)^[1]
Dosage:	1, 2, 5, 10, 15, 25, 50, 100 μmol/kg
Administration:	IV; 10 min before Pentobarbital (60 mg/kg, i.p.)
Result:	Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.

References

[1] Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6. DOI:10.1016/j.brainresbull.2010.02.007

PYR-GLU-PRO-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PYR-GLU-PRO-NH2 Suppliers

China 66 Germany 1 Switzerland 1 United Kingdom 1 United States 7 Global 76

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Nanjing Leon Biological Technology Co., Ltd.

Tel: 025-84523390 -127; 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303;
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4801
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7618
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

85541-78-2, PYR-GLU-PRO-NH2Related Search:

thyrotropin-releasing hormone, 1-Me- TRH-GLY TRH PYR-HIS-PRO-BETANA PYR-HIS-PRO-AMC Thyrotropin-releasing hormone TRH 5-OXO-5-PYRROLIDIN-1-YL-PENTANOIC ACID PYR-GLU-PRO-NH2

pyroglutamyl-glutamyl-prolineamide

fertilization promoting peptide

GLP-GLU-PRO-NH2: GLP-EP-NH2

pGlu-Glu-Pro-NH2

PYR-GLU-PRO-NH2

PYROGLU-GLU-PRO AMIDE

PGLU-GLU-PRO AMIDE

PE-E-P-NH2

FPP, Fertilization-ProMoting Peptide

FPP

GLP-GLU-PRO-NH2

(GLU2)-THYROTROPIN-RELEASING HORMONE

(GLU2)-TRH

L-Prolinamide, 5-oxo-L-prolyl-L-α-glutamyl-

(Glu2)-TRH Pyr-Glu-Pro-NH2

5-Oxo-L-prolyl-L-α-glutamyl-L-prolinamide

(S)-5-((S)-2-Carbamoylpyrrolidin-1-yl)-5-oxo-4-((S)-5-oxopyrrolidine-2-carboxamido)pentanoic acid

85541-78-2

C15H22N4O6

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

TRH

Releasing Factors