4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Property

Melting point:

226-227.5°

storage temp. 

Store at -20°C

solubility 

insoluble in H2O; ≥10.31 mg/mL in DMSO; ≥2.96 mg/mL in EtOH with gentle warming and ultrasonic

form 

solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Haloperidol Hydrochloride is the salt analogue of Haloperidol (H103700) a dopamine inverse agonist, antidyskinetic and antipsychotic agent.

Biological Activity

haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine. in addition, haloperidol hydrochloride has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function. besides, haloperidol hydrochloride has shown about 50-fold potency than chiorpromazine, the other antipsychotic drug. haloperidol hydrochloride has shown beneficial effects in the treatment of delusions and hallucinations. these effects are mainly achieved through blockage of dopamine receptors in the mesocortex and limbic system. haloperidol hydrochloride has been revealed to prevent the effects of dopamine in the nigrostriatal pathways, which probably explains the associated side effects such as akathisia and dystonias[1].

storage

Room temperature

References

[1] dr ananya mandal, md .haloperidol pharmacology.