REVERSIN 121

Product Name: REVERSIN 121
CAS No.: 174630-04-7
Chemical Name: REVERSIN 121
Synonyms: REVERSIN 121;BOC-ASP(OBZL)-LYS(Z)-OTBU;L-Lysine, N-[(1,1-dimethylethoxy)carbonyl]-L-α-aspartyl-N6-[(phenylmethoxy)carbonyl]-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester
CBNumber: CB8699257
Molecular Formula: C34H47N3O9
Formula Weight: 641.75
MOL File: Mol file

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REVERSIN 121 Property

Melting point:: 200°C
Boiling point:: 786.8±60.0 °C(Predicted)
Density: 1.163±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO or ethanol: soluble
form: powder
pka: 10.75±0.46(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R1276
Product name: Reversin 121
Purity: ≥97% (HPLC), powder
Packaging: 3mg
Price: $451
Updated: 2025/07/31

Cayman Chemical

Product number: 18603
Product name: Reversin 121
Purity: ≥98%
Packaging: 500μg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 18603
Product name: Reversin 121
Purity: ≥98%
Packaging: 1mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 18603
Product name: Reversin 121
Purity: ≥98%
Packaging: 5mg
Price: $198
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PEP0004566
Product name: REVERSIN 121
Purity: 95.00%
Packaging: 3MG
Price: $874.34
Updated: 2021/12/16

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REVERSIN 121 Chemical Properties,Usage,Production

Description

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a K_d value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.

Uses

Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.

General Description

Reversin 121 is an analog of reversin and a dipeptide derivative.

Biochem/physiol Actions

Peptide chemosensitizer, inhibitor of P-glycoprotein.

in vivo

Reversin 121 (2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day, i.p.) decreases tumor size and prevalence of metastases^[1].

Animal Model:	Orthotopic pancreatic carcinoma mouse model^[1].
Dosage:	2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day
Administration:	Intraperitoneal injection (i.p.), 5 days a week
Result:	Decreased in MRP3-positive cells.

References

[1] FRANCES J SHAROM . Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells[J]. Biochemical pharmacology, 1999, 58 4: Pages 571-586. DOI: 10.1016/s0006-2952(99)00139-2
[2] EUNICE L KWAK. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 21: 7665-7670. DOI: 10.1073/pnas.0502860102
[3] PRIYANKA S. RANA . Calibration and characterization of intracellular Asante Potassium Green probes, APG-2 and APG-4[J]. Analytical biochemistry, 2019, 567: Pages 8-13. DOI: 10.1016/j.ab.2018.11.024

REVERSIN 121 Preparation Products And Raw materials

Raw materials

Preparation Products

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REVERSIN 121 Suppliers

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174630-04-7, REVERSIN 121Related Search:

REVERSIN 121

BOC-ASP(OBZL)-LYS(Z)-OTBU

L-Lysine, N-[(1,1-dimethylethoxy)carbonyl]-L-α-aspartyl-N6-[(phenylmethoxy)carbonyl]-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester

174630-04-7

C34H47N3O9

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

P-Glycoprotein

P to Q

Biochemicals and Reagents

BioChemical