ChemicalBook > CAS DataBase List > Vanillyl alcohol

Vanillyl alcohol

Product Name
Vanillyl alcohol
CAS No.
498-00-0
Chemical Name
Vanillyl alcohol
Synonyms
4-HYDROXY-3-METHOXYBENZYL ALCOHOL;Vanillin alcohol;Vanillinol;VANILLYL ALCOHOL(RG);4-Hydroxy-3-Methoxybenze-neMenthanol;4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL);NSC 3993;vanillol;Vanillyl;FEMA 3737
CBNumber
CB8709532
Molecular Formula
C8H10O3
Formula Weight
154.16
MOL File
498-00-0.mol
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Vanillyl alcohol Property

Melting point:
110-117 °C (lit.)
Boiling point:
237.52°C (rough estimate)
Density 
1.1690 (rough estimate)
refractive index 
1.4620 (estimate)
FEMA 
3737 | VANILLYL ALCOHOL
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
Fine Crystalline Powder
pka
9.75±0.18(Predicted)
color 
Off-white to beige
Odor
at 100.00 %. sweet creamy vanilla caramellic coconut graham cracker tonka milky powdery
Odor Type
creamy
biological source
synthetic
Water Solubility 
Soluble in 95% ethanol (5 %), water, and oils.
JECFA Number
886
BRN 
1910044
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
LogP
0.42
CAS DataBase Reference
498-00-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-3-methoxybenzyl alcohol(498-00-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29095090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W373702
Product name
Vanillyl alcohol
Purity
≥98%, FG
Packaging
1 unit
Price
$53.48
Updated
2025/07/31
Sigma-Aldrich
Product number
W373702
Product name
Vanillyl alcohol
Purity
≥98%, FG
Packaging
1 unit
Price
$53.48
Updated
2025/07/31
Sigma-Aldrich
Product number
W373702
Product name
Vanillyl alcohol
Purity
≥98%, FG
Packaging
100g
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
W373702
Product name
Vanillyl alcohol
Purity
≥98%, FG
Packaging
1kg
Price
$399
Updated
2025/07/31
Sigma-Aldrich
Product number
175536
Product name
4-Hydroxy-3-methoxybenzyl alcohol
Purity
98%
Packaging
50g
Price
$54.91
Updated
2025/07/31
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Vanillyl alcohol Chemical Properties,Usage,Production

Description

4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.

Chemical Properties

Vanillyl alcohol is a lignin derived aromatic diol. It has a mild, sweet, balsamic, vanilla-like odor.  It has a potential for the production of renewable epoxy thermosets. A bio-based bisphenolic analogue, bisguaiacol, was synthesized via the electrophilic aromatic condensation of vanillyl alcohol and guaiacol. From this, the diglycidyl ether of bisguaiacol was prepared. Further, three single aromatic diglycidyl ethers were synthesized from vanillyl alcohol, gastrodigenin, and hydroquinone. 

Chemical Properties

crystalline white to off-white powder

Uses

Used as a flavoring agent. Other possible uses, vanilla, coconut, cream and other dairy nuances, coumarin.

Definition

ChEBI: Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols.

Taste threshold values

Sweet, creamy and milky with a slightly powdery mouthfeel.

General Description

Vanillyl alcohol belongs to the phenolic group of compounds which are widely used as oxidants in food products.

reaction suitability

reagent type: cross-linking reagent

Biochem/physiol Actions

Odor at 1.0%: sweet creamy, phenolic, vanilla and coconut-like with slight brown and coumarinic nuances.

Synthesis

Vanillyl alcohol is prepared from Vanillin by hydrogenation in presence of Platinum black.

References

Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.

Vanillyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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Vanillyl alcohol Suppliers

Americas 1 Belgium 1 China 354 Europe 1 France 2 Germany 6 India 11 Japan 3 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 45 Global 440
Wuhan Qiaofeng Chemical Technology Co., Ltd.
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View Lastest Price from Vanillyl alcohol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Vanillyl alcohol 498-00-0
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
300KG
Release date
2025-09-03
Anhuyan (Hainan) Biotechnology Co., LTD
Product
Vanillyl alcohol 498-00-0
Price
US $0.00-0.00/kg
Min. Order
0.001kg
Purity
99%
Supply Ability
2000000kg
Release date
2025-06-16
Anhuyan (Hainan) Biotechnology Co., LTD
Product
Vanillyl alcohol 498-00-0
Price
US $0.00/G/KG
Min. Order
1G/KG
Purity
99%
Supply Ability
10000000KG
Release date
2025-04-22

498-00-0, Vanillyl alcoholRelated Search:

4-Methoxybenzylchloride Vanillyl butyl ether Anisole Phenethyl alcohol Benzyl alcohol CHLOROPHOSPHONAZO III (Trifluoromethoxy)benzene p-Anisaldehyde 4-Nitrobenzyl alcohol Ethyl acetate 3,4,5-TRIETHOXYBENZOIC ACID 4-BENZYLOXY-3-METHOXYBENZYL ALCOHOL 4-ETHOXY-3-METHOXYBENZYL ALCOHOL 2,3,4-TRIMETHOXYBENZYL ALCOHOL 3,4-Dimethoxybenzyl alcohol 2,4,5-Trimethoxybenzoic acid Reserpine Vanillic acid

  • 3,4-Dihydroxybenzyl alcohol 3-Methyl ester
  • 4-Hydroxy-3-Methoxybenze-neMenthanol
  • Vanillinol
  • α,4-Dihydroxy-3-Methoxytoluene
  • 2-Hydroxy-5-(hydroxymethyl)anisole, 4-Hydroxy-3-methoxybenzyl alcohol, Vanillyl alcohol
  • 4-Hydroxy-3-Methoxybenzyl alcohol, 99% 50GR
  • 3-Methoxy-4-hydroxybenzyl alcohol
  • Vanillic alcohol
  • Vanillin alcohol
  • 4-HYDROXY-3-METHOXYBENZYL ALCOHOL, 98+%
  • 4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL)
  • 4-Hydroxy-3-methoxybenzyl alcohol,99%
  • VANILLYL ALCOHOL(RG)
  • Hydroxy-3-Methoxybenzyl alc
  • 4-Hydroxy-3-Methoxybenzyl alcohol 98%
  • NSC 3993
  • Vanillin Impurity 3
  • 4-HYDROXY-3-METHOXYBENZYL ALCOHOL
  • 4-hydroxy-3-methoxy-benzenemethano
  • 4-hydroxy-3-methoxybenzyl
  • 4-hydroxy-3-methoxybenzylalcohol(vanillicalcohol)
  • Benzenemethanol, 4-hydroxy-3-methoxy-
  • vanillol
  • RARECHEM AL BD 0101
  • VANILLYL ALCOHOL
  • VANILLYL ALCOHOL MI
  • VANILLYL ALCOHOL 98+%
  • Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol)
  • Vanillyl
  • FEMA 3737
  • A 4-DIHYDROXY-3-METHOXYTOLUENE
  • CITRONELLOL, D-(SG)
  • HOMOVANILLICALCOHOL
  • 4-HYDROXY-3-METHOXYBENZENEMETHANOL
  • 4-HYDROXYMETHYL-2-METHOXY-PHENOL
  • 4-Hydroxy-3-methoxybenzyl alcohol USP/EP/BP
  • para-vanillyl alcohol
  • 4-Hydroxy-3-Methoxybenzyl Alcohol CAS 498-00-0 C8h10o3
  • TIANFU-CHEM 498-00-0 4-Hydroxy-3-methoxybenzyl alcohol
  • HEXADECYL 2-ETHYLHEXANOATE 59130-69-7
  • Vanillyl alcohol (6CI, 8CI)
  • Vanillyl Alcohol, ≥ 98.0%
  • Vanillyl Alcohol (Vanillin)
  • 498-00-0
  • 4980-00-0
  • 2560-07-7
  • HOC6H3CH2OHOCH3
  • HOC6H3OCH3CH2OH
  • CH3OC6H3OHCH2OH
  • ALCOHOL
  • Oxygen Compounds
  • Organic Building Blocks
  • Building Blocks
  • Alcohols
  • C7 to C8
  • Inhibitors
  • Bifunctional Linkers
  • Linkers and Crosslinkers