2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
- Product Name
- 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
- CAS No.
- 41933-33-9
- Chemical Name
- 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
- Synonyms
- EcDsbB-IN-9;OTAVA-BB BB0128630032;EcDsbBIN9,EcDsbB IN 9;EcDsbB-IN-9, 10 mM in DMSO;2-BENZYL-4,5-DICHLOROPYRIDAZIN-3(2H)-ONE;2-BENZYL-4,5-DICHLOROPYRIDAZINE-3(2H)-ONE;2-benzyl-4,5-dichloro-2,3-dihydropyridazinone;2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE;4,5-dichloro-2-(phenylmethyl)-3(2H)-Pyridazinone;3(2H)-Pyridazinone, 4,5-dichloro-2-(phenylmethyl)-
- CBNumber
- CB8722418
- Molecular Formula
- C11H8Cl2N2O
- Formula Weight
- 255.1
- MOL File
- 41933-33-9.mol
2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Property
- Melting point:
- 86 °C(Solv: hexane (110-54-3))
- Boiling point:
- 338.0±52.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.51±0.20(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B275638
- Product name
- 2-Benzyl-4,5-dichloropyridazin-3(2H)-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B275638
- Product name
- 2-Benzyl-4,5-dichloropyridazin-3(2H)-one
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B305
- Product name
- 2-benzyl-4,5-dichloro-2,3-dihydropyridazinone
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- HCH0018424
- Product name
- 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- HCH0018424
- Product name
- 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Chemical Properties,Usage,Production
Uses
EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC50 of 1.7 μM and a Ki of 46 nM[1].
Synthesis
932-22-9
100-39-0
41933-33-9
To a round bottom flask was added 4,5-dichloropyridazin-3(2H)-one (50 g, 303.03 mmol), N,N-dimethylformamide (DMF, 150 mL), potassium carbonate (K2CO3, 46 g, 333.33 mmol) and benzyl bromide (51.83 g, 303.03 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was slowly poured into water (500 mL) and a solid precipitate was precipitated. The suspension was continued to be stirred at room temperature for 1 hour. Subsequently, the solid product was separated by filtration and dried under vacuum to afford 2-benzyl-4,5-dichloropyridazin-3(2H)-one as a tan solid (74 g, 97% yield). The product was analyzed by high performance liquid chromatography (HPLC, Method A) with a retention time of 2.788 min; liquid chromatography-mass spectrometry (LCMS) showed a molecular ion peak (M+1) of 255.1.
References
[1] Landeta C, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr;11(4):292-8. DOI:10.1038/nchembio.1752
2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE manufacturers
- Product
- 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE 41933-33-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02