ChemicalBook > CAS DataBase List > 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE

2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE

Product Name: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
CAS No.: 41933-33-9
Chemical Name: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
Synonyms: EcDsbB-IN-9;OTAVA-BB BB0128630032;EcDsbBIN9,EcDsbB IN 9;EcDsbB-IN-9, 10 mM in DMSO;2-BENZYL-4,5-DICHLOROPYRIDAZIN-3(2H)-ONE;2-BENZYL-4,5-DICHLOROPYRIDAZINE-3(2H)-ONE;2-benzyl-4,5-dichloro-2,3-dihydropyridazinone;2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE;4,5-dichloro-2-(phenylmethyl)-3(2H)-Pyridazinone;3(2H)-Pyridazinone, 4,5-dichloro-2-(phenylmethyl)-
CBNumber: CB8722418
Molecular Formula: C11H8Cl2N2O
Formula Weight: 255.1
MOL File: 41933-33-9.mol

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2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Property

Melting point:: 86 °C(Solv: hexane (110-54-3))
Boiling point:: 338.0±52.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.51±0.20(Predicted)
form: Solid
color: White to off-white

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B275638
Product name: 2-Benzyl-4,5-dichloropyridazin-3(2H)-one
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B275638
Product name: 2-Benzyl-4,5-dichloropyridazin-3(2H)-one
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: B305
Product name: 2-benzyl-4,5-dichloro-2,3-dihydropyridazinone
Packaging: 1g
Price: $88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0018424
Product name: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
Purity: 95.00%
Packaging: 1G
Price: $721.57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0018424
Product name: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
Purity: 95.00%
Packaging: 2.5G
Price: $983.88
Updated: 2021/12/16

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2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Chemical Properties,Usage,Production

Uses

EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC50 of 1.7 μM and a Ki of 46 nM[1].

Synthesis

932-22-9

100-39-0

41933-33-9

To a round bottom flask was added 4,5-dichloropyridazin-3(2H)-one (50 g, 303.03 mmol), N,N-dimethylformamide (DMF, 150 mL), potassium carbonate (K2CO3, 46 g, 333.33 mmol) and benzyl bromide (51.83 g, 303.03 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was slowly poured into water (500 mL) and a solid precipitate was precipitated. The suspension was continued to be stirred at room temperature for 1 hour. Subsequently, the solid product was separated by filtration and dried under vacuum to afford 2-benzyl-4,5-dichloropyridazin-3(2H)-one as a tan solid (74 g, 97% yield). The product was analyzed by high performance liquid chromatography (HPLC, Method A) with a retention time of 2.788 min; liquid chromatography-mass spectrometry (LCMS) showed a molecular ion peak (M+1) of 255.1.

References

[1] Landeta C, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr;11(4):292-8. DOI:10.1038/nchembio.1752

2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Suppliers

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View Lastest Price from 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE manufacturers

Dideu Industries Group Limited

Product: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE 41933-33-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

41933-33-9, 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONERelated Search:

4,5-DICHLORO-2-(4-METHYLBENZYL)-2,3-DIHYDROPYRIDAZIN-3-ONE 2-(2-CHLORO-6-FLUOROBENZYL)-4,5-DICHLOROPYRIDAZINE-3-(2H)-ONE AURORA 12480 4,5-DICHLORO-2-(2,6-DICHLOROBENZYL)-2,3-DIHYDROPYRIDAZIN-3-ONE AURORA 12806 4,5-DICHLORO-2-(2-FLUOROBENZYL)PYRIDAZINE-3(2H)-ONE AURORA 12558 4,5-DICHLORO-2-(4-CHLOROBENZYL)-2,3-DIHYDROPYRIDAZIN-3-ONE AURORA 12581 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE AURORA 12539

OTAVA-BB BB0128630032

2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE

2-BENZYL-4,5-DICHLOROPYRIDAZIN-3(2H)-ONE

2-BENZYL-4,5-DICHLOROPYRIDAZINE-3(2H)-ONE

2-benzyl-4,5-dichloro-2,3-dihydropyridazinone

4,5-dichloro-2-(phenylmethyl)-3(2H)-Pyridazinone

2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE ISO 9001：2015 REACH

EcDsbB-IN-9

EcDsbBIN9,EcDsbB IN 9

3(2H)-Pyridazinone, 4,5-dichloro-2-(phenylmethyl)-

EcDsbB-IN-9, 10 mM in DMSO

41933-33-9