4-(TRIFLUOROMETHYL)CYCLOHEXANOL

Product Name: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
CAS No.: 30129-18-1
Chemical Name: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
Synonyms: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL;4-(TRIFLUOROMETHYL)CYCLOHEXAN-1-OL;Cyclohexanol, 4-(trifluoromethyl)-;4-(trifluoromethyl)-1-cyclohexanol;1-Hydroxy-4-(trifluoromethyl)cyclohexane;4-(TRIFLUOROMETHYL)CYCLOHEXANOL, CIS/TRANS;4-(TRIFLUOROMETHYL)CYCLOHEXANOL (CIS/TRANS MIXTURE);4-(trifluoromethyl)cyclohexan-1-ol, cis/trans mixture;4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture);4-(Trifluoromethyl)cyclohexanol (mixture of cis-and trans-)
CBNumber: CB8726496
Molecular Formula: C7H11F3O
Formula Weight: 168.16
MOL File: 30129-18-1.mol

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4-(TRIFLUOROMETHYL)CYCLOHEXANOL Property

Boiling point:: 78 °C
Density: 1.23
refractive index: 1.4070 to 1.4110
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
pka: 14.88±0.40(Predicted)
color: Colorless to Almost colorless
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C7H11F3O/c8-7(9,10)5-1-3-6(11)4-2-5/h5-6,11H,1-4H2
InChIKey: VJUJYNJEPPWWHS-UHFFFAOYSA-N
SMILES: C1(O)CCC(C(F)(F)F)CC1

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36
RIDADR: 1993
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2906190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000014
Product name: 4-(Trifluoromethyl)cyclohexanol
Purity: Aldrich
Packaging: 1g
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: T2706
Product name: 4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture)
Purity: >98.0%(GC)
Packaging: 5g
Price: $173
Updated: 2025/07/31

TRC

Product number: T797043
Product name: 4-(Trifluoromethyl)cyclohexanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2202-3-04
Product name: 4-(Trifluoromethyl)cyclohexanol
Purity: 97%
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 005400
Product name: 4-(Trifluoromethyl)cyclohexanol
Purity: 97%
Packaging: 1g
Price: $47
Updated: 2021/12/16

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4-(TRIFLUOROMETHYL)CYCLOHEXANOL Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

402-45-9

75091-92-8

Step A: Synthesis of 4-(trifluoromethyl)cyclohexanol; 4-hydroxytrifluorotoluene (5 g, 30.8 mmol) was placed in a high-pressure hydrogenation reactor, dissolved in acetic acid (15 ml) and platinum oxide (PtO, 500 mg) was added as a catalyst. The reactor was pressurized using hydrogen (50 psi) and the reaction was carried out at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the pH was adjusted by adding 1N sodium hydroxide solution to the filtrate, followed by extraction with diethyl ether. The organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure at room temperature to afford the target product 4-(trifluoromethyl)cyclohexanol (4.5 g, 87% yield). Mass spectrometry analysis showed [M + H]+ peak of 169, corresponding to the molecular ion peak (M + 1).

References

[1] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 27
[2] , 1970, vol. 6, # 10, p. 2063 - 2067
[3] Zhurnal Organicheskoi Khimii, 1970, vol. 6, # 10, p. 2055 - 2060

4-(TRIFLUOROMETHYL)CYCLOHEXANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(TRIFLUOROMETHYL)CYCLOHEXANOL Suppliers

Belgium 1 China 101 France 1 Germany 3 India 5 Japan 1 United Kingdom 8 United States 15 Global 135

Taizhou Tianhong Biochemistry Technology Co., Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Shanghai Ennopharm Co., Ltd.

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View Lastest Price from 4-(TRIFLUOROMETHYL)CYCLOHEXANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL 30129-18-1
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Shanghai Yongzeng Technology Co.,Ltd

Product: 4-(trifluoromethyl)cyclohexanol 30129-18-1
Price: US $0.00/gm
Min. Order: 100gm
Purity: 97%min
Supply Ability: 100kgs
Release date: 2024-09-10

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL 30129-18-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-18

30129-18-1, 4-(TRIFLUOROMETHYL)CYCLOHEXANOLRelated Search:

4-(TRIFLUOROMETHYL)CYCLOHEXAN-1-OL

4-(TRIFLUOROMETHYL)CYCLOHEXANOL

4-(TRIFLUOROMETHYL)CYCLOHEXANOL, CIS/TRANS

4-(TRIFLUOROMETHYL)CYCLOHEXANOL (CIS/TRANS MIXTURE)

4-(Trifluoromethyl)cyclohexanol (mixture of cis-and trans-)

4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture)

1-Hydroxy-4-(trifluoromethyl)cyclohexane

4-(Trifluoromethyl)cyclohexanol (<i>cis</i>- and <i>trans</i>- mixture)

4-(trifluoromethyl)-1-cyclohexanol

Cyclohexanol, 4-(trifluoromethyl)-

4-(trifluoromethyl)cyclohexan-1-ol, cis/trans mixture

30129-18-1

454-63-8

C7H11F3O

Ring Systems