ChemicalBook > CAS DataBase List > L(+)-Homoarginine hydrochloride

L(+)-Homoarginine hydrochloride

Product Name
L(+)-Homoarginine hydrochloride
CAS No.
1483-01-8
Chemical Name
L(+)-Homoarginine hydrochloride
Synonyms
NSC 145416;HomoArg.HCl;H-HAR-OH HCL;-(+)-Homoarg;L-Homoarg.hcl;H-HArg-OH·HCl;inine hydrochL;H-L-HArg-OH*HCl;H-HOMOARG-OH HCL;H-L-HOARG-OH HCL
CBNumber
CB8732118
Molecular Formula
C7H17ClN4O2
Formula Weight
224.69
MOL File
1483-01-8.mol
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L(+)-Homoarginine hydrochloride Property

Melting point:
213-215 °C(lit.)
alpha 
18 º (c=1, 1N HCl)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 50 mg/mL, clear to slightly hazy, faintly yellow
form 
Granular Powder
color 
White
Water Solubility 
Soluble in water(50 mg/mL).
BRN 
4016621
Stability:
Moisture Sensitive
CAS DataBase Reference
1483-01-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1007
Product name
L-Homoarginine hydrochloride
Purity
unnatural arginine analog
Packaging
5g
Price
$350
Updated
2024/03/01
TCI Chemical
Product number
H1172
Product name
L-Homoarginine Hydrochloride
Purity
>97.0%(T)
Packaging
1g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
H1172
Product name
L-Homoarginine Hydrochloride
Purity
>97.0%(T)
Packaging
5g
Price
$188
Updated
2024/03/01
Alfa Aesar
Product number
H27387
Product name
L-Homoarginine hydrochloride, 98+%
Packaging
1g
Price
$65.65
Updated
2024/03/01
Alfa Aesar
Product number
H27387
Product name
L-Homoarginine hydrochloride, 98+%
Packaging
5g
Price
$255
Updated
2024/03/01
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L(+)-Homoarginine hydrochloride Chemical Properties,Usage,Production

Description

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.

Chemical Properties

White Powder

Uses

An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).

Uses

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Biochem/physiol Actions

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

L(+)-Homoarginine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L(+)-Homoarginine hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Homoarg.hcl 1483-01-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Homoarginine Hydrochloride 1483-01-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
50g
Purity
98.0%-101.5%
Supply Ability
100kg
Release date
2021-06-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L(+)-Homoarginine hydrochloride 1483-01-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
5000kg/month
Release date
2021-10-13

1483-01-8, L(+)-Homoarginine hydrochlorideRelated Search:

ARGINASE L(+)-Arginine Homoarginine Topotecan hydrochloride 6-Aminocaproic acid L-Arginine hydrochloride Glycine Boc-N'-Nitro-L-homoarginine FMOC-HOMOARG(PMC)-OH N-ALPHA-T-BUTOXYCARBONYL-L-HOMOARGININE HYDROCHLORIDE,Boc-L-Homoarginine hydrochloride arginine aspirin D-Homoarginine hydrochloride 6-GUANIDINOHEXANOIC ACID FMOC-HOMOARG-OH Fmoc-N-Pbf-L-HomoArginine FMOC-L-HOMOARGININE, HYDROCHLORIDE SALT BOC-HOMOARG(ET)2-OH Z-HOMOARG-OH

  • L-HOMOARGININE HYDROCHLORIDE, UNNATU
  • L-Homoarg.hcl
  • L-(S)-2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
  • L(+)-HOMOARGININE HCL
  • L-HOMOARGININE HCL
  • L(+)-HOMOARGININE HYDROCHLORIDE
  • L-HOMOARGININE HYDROCHLORIDE
  • L-HOMOARGININE MONOHYDROCHLORIDE
  • H-HAR-OH HCL
  • H-HOMOARG-OH HCL
  • H-HOMOARG-OH HYDROCHLORIDE
  • H-HArg-OH·HCl
  • 2-AMINO-6-GUANIDINO-HEXANOIC ACID, HCL
  • 2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
  • (S)-2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
  • HOMOARGININE HYDROCHLORIDE
  • H-L-HOARG-OH HCL
  • N6- (AMINOIMINOMETHYL)-L-LYSINE
  • L-HomoarginineHydrochloride>99%
  • H-L-HArg-OH*HCl
  • L-Homoarginine hydrochloride, (S)-2-Amino-6-guanidinohexanoic acid hydrochloride
  • L-Homoarginine hydrochloride, 98+%
  • 2-Amino-6-(diaminomethylideneamino)hexanoic acid hydrochloride
  • L-Lysine, N(6)-(aminoiminomethyl)-, monohydrochloride
  • L-(+)-Homarginine Hydrochloride
  • L-Homoarginine hydrochloride (H-Harg-OH·HCl) ,98%
  • HomoArg.HCl
  • L(+)-Homoarginine hy
  • L-Lysine,N6-(aminoiminomethyl)-, hydrochloride (1:1)
  • (2S)-2-ammonio-6-(diaminomethylideneammonio)hexanoate
  • L-HomoarginineHydrochloride&gt
  • NSC 145416
  • -(+)-Homoarg
  • inine hydrochL
  • -(+)-Homoarginine hydrochL
  • L(+)-Homoarginine hydrochloride USP/EP/BP
  • L-Homoarginine Hydrochloride, ≥ 97.0%
  • 1483-01-8
  • H2NCNHNHCH24CHNH2CO2HHCl
  • C7H16N4O2HCl
  • C7H16N4O2ClH
  • C7H16N4O2xHCl
  • H2NCNHNHCH24NH2CO2HHCl
  • C7H17ClN4O2
  • The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes.
  • Homo-Amino Acids
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Aliphatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Amino Acids & Derivatives
  • Nitric Oxide Reagents
  • Homoarginine [HomoArg]
  • Amino Acids 13C, 2H, 15N