2-Tetrahydrofurfurylamine Property

Melting point:

136 °C

Boiling point:

153-154 °C744 mm Hg(lit.)

Density 

0.98 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.454(lit.)

Flash point:

114 °F

storage temp. 

Flammables area

solubility 

Chloroform, Methanol

pka

9.47±0.29(Predicted)

form 

Liquid

color 

Clear colorless to light yellow

explosive limit

1.6-14.1%(V)

Water Solubility 

miscible

Sensitive 

Air Sensitive & Hygroscopic

BRN 

102729

LogP

-0.348 (est)

CAS DataBase Reference

4795-29-3(CAS DataBase Reference)

NIST Chemistry Reference

2-Furanmethanamine, tetrahydro-(4795-29-3)

EPA Substance Registry System

Tetrahydrofurfurylamine (4795-29-3)

Safety

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-36-37/39-16

RIDADR 

UN 2943 3/PG 3

WGK Germany 

3

RTECS 

LV0175000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29321900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Tetrahydrofurfurylamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light-yellow liquid. Distilling range 150– 156C, d 0.977 (20C/20C). Combustible.

Uses

Chemical intermediate, fine-grain photographic development, vulcanization accelerator.

Uses

Tetrahydro-2-furanmethanamine is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors

General Description

A colorless to light yellow liquid. Insoluble in water and less dense than water. Flash point between 100 - 141°F. Used to make other chemicals and as a photographic chemical.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

2-Tetrahydrofurfurylamine is an amine and alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by intraperitoneal route. Flammable liquid when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also MINES.