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Dibutyl sebacate

Product Name
Dibutyl sebacate
CAS No.
109-43-3
Chemical Name
Dibutyl sebacate
Synonyms
PARAROSANILINE;MAGENTA;MAGENTA O;PARAFUCHSIN HYDROCHLORIDE;BASIC FUCHSIN HYDROCHLORIDE;Dibutyl Sebacate (1 mL) (AS);RUBIN;px404;ROSEIN;PX 404
CBNumber
CB8737502
Molecular Formula
C18H34O4
Formula Weight
314.46
MOL File
109-43-3.mol
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Dibutyl sebacate Property

Melting point:
205 °C (dec.)(lit.)
Boiling point:
178-179 °C3 mm Hg(lit.)
Density 
0.94
vapor pressure 
0.001Pa at 25℃
FEMA 
2373 | DIBUTYL SEBACATE
refractive index 
n20/D 1.441(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
hexane, toluene, ethanol and acetone: soluble
form 
Liquid
Specific Gravity
0.937 (20/4℃)
color 
Clear
Odor
at 100.00 %. faint fruity oily
Odor Type
fruity
Water Solubility 
50mg/L(temperature not stated)
JECFA Number
625
BRN 
1798308
Dielectric constant
4.5（30℃）
LogP
6.30
CAS DataBase Reference
109-43-3(CAS DataBase Reference)
NIST Chemistry Reference
Di-n-butyl sebacate(109-43-3)
EPA Substance Registry System
Dibutyl sebacate (109-43-3)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
40-36/37/38
Safety Statements 
36/37-36-26
WGK Germany 
3
RTECS 
VS1150000
TSCA 
Yes
HS Code 
29171390
Hazardous Substances Data
109-43-3(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 14870mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1187091
Product name
Dibutyl sebacate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1ml
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
80865
Product name
Dibutyl sebacate
Purity
analytical standard
Packaging
1ml
Price
$72.9
Updated
2022/05/15
Sigma-Aldrich
Product number
8.17067
Product name
Dibutyl sebacate
Purity
NF
Packaging
1L
Price
$246
Updated
2022/05/15
TCI Chemical
Product number
S0023
Product name
Dibutyl Sebacate
Purity
>98.0%(GC)
Packaging
25mL
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
S0023
Product name
Dibutyl Sebacate
Purity
>98.0%(GC)
Packaging
500mL
Price
$70
Updated
2024/03/01
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Dibutyl sebacate Chemical Properties,Usage,Production

Description

Dibutyl sebacate is a colorless oily liquid. Insoluble in water, soluble in alcohol, miscible with oils. Poorly soluble in Propylene glycol.Fruity, but very mild and oily odor of considerable tenacity.

Chemical Properties

Dibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.

Uses

Dibutyl sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.It has been used as a plasticizer to prepare free ethylcellulose films. It can be utilized as a core in liquid-core capsules with cross-linked alginate/polyacrylamide membrane prepared via co-extrusion jet-break-up method for the extraction of the pesticide, atrazine.

Preparation

Dibutyl sebacate can be obtained by distilling sebacic acid and butanol from concentrated HCl in benzene or by reacting butanol with sebacic acid chloride.

Production Methods

Dibutyl sebacate is manufactured by the esterification of n-butanol and sebacic acid in the presence of a suitable catalyst, and by the distillation of sebacic acid with n-butanol in the presence of concentrated acid.

Definition

ChEBI: Dibutyl decanedioate is a fatty acid ester.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.
Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products;for example,up to 5ppm is used in ice cream and nonalcoholic beverages.

Safety Profile

Mddly toxic by ingestion. Experimental reproductive effects. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2 position it emits acrid smoke and fumes. See also ESTERS and n-BUTYL. ALCOHOL.

Safety

Dibutyl sebacate is used in cosmetics, foods, and oral pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Following oral administration, dibutyl sebacate is metabolized in the same way as fats. In humans, direct eye contact and prolonged or repeated contact with the skin may cause very mild irritation. Acute animal toxicity tests and long-term animal feeding studies have shown no serious adverse effects to be associated with orally administered dibutyl sebacate.
LD50 (rat, oral): 16g/kg

storage

Dibutyl sebacate should be stored in a closed container in a cool, dry location. Dibutyl sebacate is stable under the recommended storage conditions and as used in specified applications under most conditions ofuse.Asanester,dibutylsebacatemayhydrolyzeinthe presence of water at high or low pH conditions.

Incompatibilities

Dibutyl sebacate is incompatible with strong oxidizing materials and strong alkalis.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, granules, film-coated, sustained action, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Dibutyl sebacate Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid Sebacic acid Sebacoyl chloride Castor oil tert-Butanol

Preparation Products

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Dibutyl sebacate Suppliers

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View Lastest Price from Dibutyl sebacate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dibutyl sebacate 109-43-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-22
Hebei Mujin Biotechnology Co.,Ltd
Product
Dibutyl sebacate 109-43-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Weibang Biotechnology Co., Ltd
Product
Dibutyl sebacate 109-43-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01

109-43-3, Dibutyl sebacateRelated Search:

Dibutyl maleate Decanedihydrazide Diisooctyl sebacate Dimethyl sebacate Diethyl sebacate Dioctyl sebacate Di-tert-butyl dicarbonate Sebacic acid Diisobutyl phthalate Dibutyl phosphate Dibutyl phthalate PARAROSANILINE,PARAROSANILINE BASE,PARAROSANILINE FREE BASE (C.I. 42500) Light Stabilizer 770 Bis-(1-octyloxy-2,2,6,6-tetramethyl-4-piperidinyl) sebacate DINONYL SEBACATE Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate Poly(maleicanhydride-acrylicacidcopolymer) PARAROSANILINE HYDROCHLORIDE

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  • LABOTEST-BB LT00159713
  • MAGENTA
  • MAGENTA O
  • MAGENTA O HYDROCHLORIDE
  • ROSEIN
  • ROSANILIN
  • RUBIN
  • PARAMAGENTA
  • PARAMAGENTA HYDROCHLORIDE
  • PARAFUCHSIN
  • PARAFUCHSIN HYDROCHLORIDE
  • PARAOSANILINE HCL
  • PARAROSANILINE
  • PARAROSANILIN HYDROCHLORIDE
  • PARAROSANILINE HYDROCHLORIDE
  • P-FUCHSIN
  • Decanedioic Acid 1,10-Dibutyl Ester
  • Ergoplast SDB
  • NSC 3893
  • Dibutyl sebacate,93%
  • DIBUTYL SEBACATE 109-43-3
  • polycizerdbs
  • PX 404
  • px404
  • Reomol DBS
  • Staflex DBS
  • staflexdbs
  • Uniflex DBS
  • CL 42500
  • CI NO 42500
  • BASIC FUCHSIN HYDROCHLORIDE
  • BASIC PARAFUCHSIN
  • BASIC PARAFUCHSIN HYDROCHLORIDE
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