7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

Product Name: 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
CAS No.: 62252-26-0
Chemical Name: 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Synonyms: JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-;JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
CBNumber: CB8741619
Molecular Formula: C10H8ClNO3
Formula Weight: 225.63
MOL File: 62252-26-0.mol

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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Property

Melting point:: 115 °C
Boiling point:: 456.1±45.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO (Slightly)
pka: 1.95±0.20(Predicted)
form: Solid
color: Yellow to Beige
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28712
Product name: JCP251
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28712
Product name: JCP251
Packaging: 100mg
Price: $961
Updated: 2024/03/01

Cayman Chemical

Product number: 28712
Product name: JCP251
Packaging: 50mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 28712
Product name: JCP251
Packaging: 250mg
Price: $1802
Updated: 2024/03/01

Tocris

Product number: 2677
Product name: JLK6
Purity: ≥99%(HPLC)
Packaging: 50
Price: $690
Updated: 2021/12/16

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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Usage,Production

Uses

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Definition

ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

References

[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers

China 37 United Kingdom 1 United States 11 Global 49

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62252-26-0, 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARINRelated Search:

GAMMA-SECRETASE INHIBITOR 2-(Chloromethyl)benzoic acid 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Methyl 2-chloromethylbenzoate 1H-2-Benzopyran-1-one 3-METHOXY-1H-ISOCHROMEN-1-ONE BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE 1,1-DIMETHOXYETHENE

JCP 251)

JCP251 (JCP-251

JLK6

GAMMA-SECRETASE INHIBITOR XI

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

7-Amino-4-chloro-3-methoxy-1H-2-benzopyran

7-Amino-4-chloro-3-methoxy-isochromen-1-one

7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one

1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-

JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β

62252-26-0