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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

Product Name
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
CAS No.
62252-26-0
Chemical Name
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Synonyms
JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-;JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
CBNumber
CB8741619
Molecular Formula
C10H8ClNO3
Formula Weight
225.63
MOL File
62252-26-0.mol
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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Property

Melting point:
115 °C
Boiling point:
456.1±45.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly)
pka
1.95±0.20(Predicted)
form 
Solid
color 
Yellow to Beige
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28712
Product name
JCP251
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28712
Product name
JCP251
Packaging
100mg
Price
$961
Updated
2024/03/01
Cayman Chemical
Product number
28712
Product name
JCP251
Packaging
50mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
28712
Product name
JCP251
Packaging
250mg
Price
$1802
Updated
2024/03/01
Tocris
Product number
2677
Product name
JLK6
Purity
≥99%(HPLC)
Packaging
50
Price
$690
Updated
2021/12/16
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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Usage,Production

Uses

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Definition

ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

References

[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers

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62252-26-0, 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARINRelated Search:

GAMMA-SECRETASE INHIBITOR 2-(Chloromethyl)benzoic acid 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Methyl 2-chloromethylbenzoate 1H-2-Benzopyran-1-one 3-METHOXY-1H-ISOCHROMEN-1-ONE BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE 1,1-DIMETHOXYETHENE

  • JCP 251)
  • JCP251 (JCP-251
  • JLK6
  • GAMMA-SECRETASE INHIBITOR XI
  • 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
  • 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
  • 7-Amino-4-chloro-3-methoxy-isochromen-1-one
  • 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
  • 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-
  • JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
  • 62252-26-0