ChemicalBook > CAS DataBase List > Apramycin sulfate

Apramycin sulfate

Product Name: Apramycin sulfate
CAS No.: 65710-07-8
Chemical Name: Apramycin sulfate
Synonyms: Ai3-29795;NEBRAMYCIN II;ApraMycin sulf;Nebramycin 11;Abrams sulfate;Unii-8uyl6naz3q;Einecs 265-890-7;AMPRAMYCINSULFATE;APRAMYCIN SULPHATE;Apramycin sulfater
CBNumber: CB8741912
Molecular Formula: C21H43N5O15S
Formula Weight: 637.66
MOL File: 65710-07-8.mol

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Apramycin sulfate Property

Melting point:: >168°C (dec.)
Boiling point:: 823℃
Density: 1.56
Flash point:: 451.6°(845°F)
storage temp.: Inert atmosphere,2-8°C
solubility: H2O: soluble25mg/mL
form: powder
color: white to light yellow
Water Solubility: Soluble in water.
JECFA Number: 75

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Safety

Hazard Codes: T,Xn
Risk Statements: 61-35-36/37/38-20/21/22-36/38
Safety Statements: 53-26-36/37/39-45-36
WGK Germany: 3
F: 10
HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2024
Product name: Apramycin sulfate salt
Purity: ≥95% (TLC)
Packaging: 1g
Price: $75.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: A2024
Product name: Apramycin sulfate salt
Purity: ≥95% (TLC)
Packaging: 5g
Price: $259
Updated: 2025/07/31

TCI Chemical

Product number: A3395
Product name: Apramycin Sulfate
Packaging: 5G
Price: $102
Updated: 2025/07/31

TCI Chemical

Product number: A3395
Product name: Apramycin Sulfate
Packaging: 25G
Price: $357
Updated: 2025/07/31

Cayman Chemical

Product number: 19688
Product name: Apramycin (sulfate)
Purity: ≥550 u/mg
Packaging: 500mg
Price: $26
Updated: 2021/12/16

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Apramycin sulfate Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

antibacterial; LD50(iv) 280mg/kg(mouse)

Uses

Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

Uses

Apramycin sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.

Definition

ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol.

in vivo

Apramycin (200 mg/kg/d, s.c., 9 d) sulfate demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice^[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) sulfate dose-dependently reduces bacterial burden in the kidneys between 2-5 log₁₀ and in blood between 2-3 log₁₀ for neutropenic model of Staphylococcus aureus septicemia mice^[2].
Apramycin (50 mg/kg/d, s.c., 21 d) sulfate induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)^[3].

Animal Model:	M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice ^[2]
Dosage:	200 mg/kg/d
Administration:	Subcutaneousinjection (s.c.) for 9 d
Result:	Showed a 2.4-log₁₀ CFU reduction and better antituberculous activity compared to Amikacin (1.8-log₁₀ reduction).

IC 50

Aminoglycoside

Apramycin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Apramycin sulfate Suppliers

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View Lastest Price from Apramycin sulfate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Apramycin sulfate 65710-07-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Shandong Xuhuang New material CoLTD

Product: Apramycin Sulfate 65710-07-8
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200
Release date: 2025-02-25

Hebei Yanxi Chemical Co., Ltd.

Product: Apramycin sulfate 65710-07-8
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-22

65710-07-8, Apramycin sulfateRelated Search:

Gentamicin sulfate Magnesium sulfate heptahydrate Ammonium sulfate Sodium sulfate APRAMYCIN Vanadyl sulfate Dimethyl sulfate Barium sulfate Kanamycin sulfate Zinc sulfate heptahydrate MICRONOMICIN SULFATE Neomycin sulfate Aluminum sulfate Spectinomycin sulfate tetrahydrate sulfate Apramycin sulfate Apramycin sulfate 3'-Hydroxy Apramycin

APRAMYCIN SULPHATE

APRAMYCIN SULFATE SALT

5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL

NEBRAMYCIN II SULFATE

ApraMycin sulf

Apramycin sulfate solution,1000ppm

D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:)

Apramycin sulfate Solution Solution, 100ppm

Apramycin sulfate salt, >500U/mg

NEBRAMYCIN II

NEBRAMYCIN 11 SULPHATE

AMPRAMYCINSULFATE

Nebramycin 11

4-O-((8R)-2-Amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl)-2-deoxy-D-streptamine sulfate C21H41N5O11 .XH2SO4

Apramycin·sulfuric acid

4-O-[(8R)-8-O-(4-Amino-4-deoxy-α-D-glucopyranosyl)-2-amino-7-methylamino-2,3,7-trideoxy-α-D-glycero-D-allo-octodialdo-1,5:8,4-dipyranosyl]-2-deoxy-D-streptamine/sulfuric acid,(1:x)

Ai3-29795

Apramycin, sulfate (2:5)

D-Streptamine, o-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-o-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)

Einecs 265-890-7

Unii-8uyl6naz3q

Apramycin sulfate salt,Nebramycin II

D-Streptamine, O-4-amino-4-deoxy-.alpha.-D-glucopyranosyl-(1?8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-.alpha.-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1?4)-2-deoxy-, sulfate (salt)

O-4-AMino-4-deoxy-α-D-glucopyranosyl-(18)-O-(8R)-2-aMino-2,3,7-trideoxy-7-(MethylaMino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(14)-2-deoxy-D-streptaMineSulfate

AMpraMycin sulfate API

Apramycin sulfate solution in Methanol, 100μg/mL

Apramycin sulfater

(2R,3R,4S,5S,6S)-5-Amino-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol xsulfate

Apramycin Sulfate (Nebramycin II)

Abrams sulfate

Apramycinsulfatesal

3'-Hydroxy Apramycin X-Sulfate

Nebramycin II|||Ai3-29795

C10293000 Apramycin sulfate

Apramycin sulfate in Water

Apramycin sulfate, 10 mM in DMSO

Apramycinsulfate(1:x)

65710-07-8

C21H41N5O11xH2O4S

C21H41N5O11H2O4S

C21H41N5O11xH2SO4

C21H41N5O11x25H2SO4

C21H41N5O11x2x5H2SO4

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