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N-Methyl Desloratadine

Product Name
N-Methyl Desloratadine
CAS No.
38092-89-6
Chemical Name
N-Methyl Desloratadine
Synonyms
Methyl loratadine;N-Methyl Loratadine;Loratadine EP IMpurity G;8-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;8-Chloro-6;6]cyclohepta[1;Methyl loratidine;8-Chloro azatidine;8-CHLORO AZATADINE;Loratadine USP RC B
CBNumber
CB8743800
Molecular Formula
C20H21ClN2
Formula Weight
324.85
MOL File
38092-89-6.mol
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N-Methyl Desloratadine Property

Melting point:
106-109°C
Boiling point:
474.3±45.0 °C(Predicted)
Density 
1.205±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.67±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C20H21ClN2/c1-23-11-8-14(9-12-23)19-18-7-6-17(21)13-16(18)5-4-15-3-2-10-22-20(15)19/h2-3,6-7,10,13H,4-5,8-9,11-12H2,1H3
InChIKey
VLXSCTINYKDTKR-UHFFFAOYSA-N
SMILES
C12/C(=C3\CCN(C)CC\3)/C3=CC=C(Cl)C=C3CCC1=CC=CN=2
CAS DataBase Reference
38092-89-6(CAS DataBase Reference)
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Safety

HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2308
Product name
Loratadine Related Compound B
Packaging
50MG
Price
$654
Updated
2025/07/31
Sigma-Aldrich
Product number
1370291
Product name
Loratadine Related Compound B
Packaging
15mg
Price
$1430
Updated
2025/07/31
Usbiological
Product number
268291
Product name
8-Chloro-6-
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
M316500
Product name
N-MethylDesloratadine
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
U681
Product name
8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
Packaging
5g
Price
$354
Updated
2021/12/16
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N-Methyl Desloratadine Chemical Properties,Usage,Production

Chemical Properties

Red Oil

Uses

N-Methyl Desloratadine (Loratadine EP Impurity G; Loratadine USP Related Compound B) is an intermediate in the synthesis of Loratadine. Loratadine impurity.

Uses

An intermediate in the synthesis of Loratadine. Loratadine impurity.

Synthesis

119770-60-4

38092-89-6

The general procedure for the synthesis of 8-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1 ,2-b]pyridine using (1-methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]methanone hydrochloride as a starting material was as follows: in Example 2, the preparation of 8-chloro-6,11-dihydro-1H -(N-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (XII). This was done by preparing Compound XIII (100 g) according to the standard method described in U.S. Patent No. 4,659,716 by first azeotropic de-watering in toluene without drying. Subsequently, boric acid (115 g) and concentrated sulfuric acid (415 g) were added and the reaction was heated at 105-110°C for 4-8 hours. After completion of the reaction, the reaction mixture was slowly poured into cold water and extracted with ethyl acetate. Finally, the solvent was removed by distillation under reduced pressure to afford the target product 8-chloro-11-(1-methylpiperidin-4-ylmethylene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine as a solid form in 85% yield and 99.5% purity (determined by OAB and HPLC).

References

[1] Journal of Organic Chemistry, 1989, vol. 54, # 9, p. 2242 - 2244
[2] Patent: WO2006/6184, 2006, A2. Location in patent: Page/Page column 17
[3] Patent: US6075025, 2000, A
[4] Patent: US6075025, 2000, A
[5] Patent: US5422351, 1995, A

N-Methyl Desloratadine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl Desloratadine Suppliers

Canada 1 China 244 Europe 2 India 33 United Kingdom 4 United States 15 Global 299
Shanghai RC Chemicals Co. Ltd
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17305617782
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86-21-50322176
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sales1@rcc.net.cn
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Shanghai Taijilin Industrial Co., Ltd.
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021-50630626 18964684208
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Conier Chem & Pharma Co.,Ltd,
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Anhui Dexinjia Biopharm Co., Ltd
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0531-82375892 15553111391
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Suzhou Quanhui Bio-technology Co., ltd
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Guangzhou Greensyn Co., Ltd.
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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Beijing HwrkChemical Technology Co., Ltd
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View Lastest Price from N-Methyl Desloratadine manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 38092-89-6
Price
US $150.00-2500.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2MT per month
Release date
2021-01-13
Shaanxi Dideu New Materials Co. Ltd
Product
N-Methyl Desloratadine 38092-89-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18
Wuhan Xinhao Biotechnology Co., Ltd
Product
8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 38092-89-6
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-03-11

38092-89-6, N-Methyl DesloratadineRelated Search:

Triacetonediamine Kresoxim-methyl 2,4,6-Collidine Acetonitrile Azamethiphos 2,6-Lutidine Methyl acrylate Basic Violet 1 2,2,6,6-Tetramethyl-4-piperidinol Dihydromyrcenol Methylparaben Methanol Benzo[b]thien-2-ylboronic acid 4-Methylpyridine 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Methyl Loratadine 3-Hydroxy loratadine

  • 8-chloro-11-(1-methyl-4-piperidylidenel-5,11)-dihydro-5H-benzo5,6-cyclohepta
  • 6,11ihydro-5H-Benzo-5,6Cyclohepta-L,2-BPyridine,Loratadine
  • 8-Chloro-11-(1-Methyl-4-Piperidinylidene)-6, 11-dihydro 5H-Benzo [5,6] cyclohepta (1,2-b) Pyridine
  • 6,11 –Dihydro- 5H- Benzo-5,6Cyclohepta- L,2-B Pyridine, Loratadine,
  • 8-chloro-11-(1-methyl-4-piperidylidenel-5,11)-dihydro-5H-benzo〔5,6〕-cyclohepta〔1,2-b〕pyridine
  • 8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDINYLIDENE)-5H-BENZO[5,6] CYCLOHEPTA [1,2-B]PYRIDINE =99%
  • 8-CHLORO-11-(L-METHYL-4-PIPERIDINYLIDENE-6,11-DIHYDRO-5H-BENZO[5.6])CYCLOHEPTA[L,2-B]PYRIDINE
  • 8-CHLORO-11-(1-METHYL-4-PIPERIDYLIDENEL-5,11)-DIHYDRO-5H-BENZOK5,6L-CYCLOHEPTA
  • 8-Chloro azatidine
  • 11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5
  • 8-Chloro-6,11-dihydro-11-(N-methyl-4-piperinylidene)-5H-benzo[5,6]cyclohepta[1,2-b] pyridine
  • 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine,8-chloro-6
  • Loratadine EP Impurity G (Methyl Loratadine)
  • Loratadine Impurity 7(Loratadine EP Impurity G)(USP-B)
  • 6]cyclohepta[1
  • 8-Chloro-6
  • Nitromethyl desloratadine
  • Loratadine Impurity G, USP related compound B
  • Loratadine Impurity 5/Loratadine EP Impurity G
  • Loratadine Related Compound B (15 mg) (8-Chloro-6,11-dihydro-11-(N-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine)
  • 8-Chloro-6,11-dihydro-11-(1-Methyl-4-piperidinylid
  • Methyl loratadine
  • 8-Chloro-6,11-dihydro-11(N-Methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • Loratadine Related CoMpound B
  • 8-Chloro-6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-
  • Loratadine EP IMpurity G
  • 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro- 11-(1-Methyl-4-piperidinylidene)-
  • Desloratadine N-Methyl Impurity
  • 8-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • 8-CHLORO-11-(1-METHYL-4-PIPERIDINYLIDENE-611-DIHYDRO-5H-BNZO[5,6]) CYCLOHEPTA[1,2-B]PYRIDINE (METHYL LORATADINE)
  • Methyl Desloratadine
  • 8 Chloro-11-[(N-methyl)-4-piperidylidene]-6, 11-dihydro-5H-benzo [5,6]cyclohepta (1,2b) Pyridine (Methyl Loratadine)
  • 8-CHLORO-11-(1-METHYL-4-PIPERIDINYLIDENE-6,11-DIHYDRO-5H-BNZO[5.6])CYCLOHEPTA[1,2-B]PYRIDINE
  • 8-CHLORO-11-(1-METHYL-4-PIPERIDYLIDENE)-6,11-DIHYDRO-5H-BENZO(5,6)CYCLOHEPTAL[1,2-B]PYRIDINE
  • 8-CHLORO AZATADINE
  • 8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
  • 8-Chloro-11-(1-Methyl-4-Piperidylidene-5,11)-Dihydro-5h-Benzo(5,6)Cycloheptal[1,2-B]Pyridine
  • 8-Chloro-11-(1-Methyl-4-Piperidylidene-5,11)-Dihydro-5h-Benzo(5,6)Cyclohepta[1,2-B]Pyridine
  • 8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTO[1,2-B]PYRIDINE-11-ONE
  • Rupatadine EP Impurity
  • 8-CHLORO-6 11-DIHYDRO-11-(1-METHYL)-4-PI PERDYLIDENE BENZO (5 6) CYCLOHEPTA 1 2B PYRIDINE (8-CHLOROAZATADINE)
  • 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine (Methyl Loratadine)
  • 8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4PIPERIDINYLIDENE)-5H-BENZO(5,6)CYCLOHEPTA(1, 2-B) PYRIDINE (8-CHLORO AZATADINE) / METHYL LORATIDINE
  • 8-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
  • N-Methyl Loratadine
  • Loratadine Impurity 7(Loratadine EP Impurity G)(Loratadine USP RC B)
  • 8-Chloroazatadine (Desloratadine Impurity)
  • Loratidine EP Impurity G/ Loratidine Related Compound B (N-Methyl Desloratadine/ 8-Chloro Azatadine)
  • N-Methyl Desloratadine (Loratidine EP Impurity G/ Loratidine Related Compound B/ 8-Chloro Azatadine)
  • 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-be...
  • Loratadine EP Impurity GQ: What is Loratadine EP Impurity G Q: What is the CAS Number of Loratadine EP Impurity G Q: What is the storage condition of Loratadine EP Impurity G Q: What are the applications of Loratadine EP Impurity G
  • Loratadine EP Impurity G (Loratadine USP Related Compound B, Methyl Loratadine)
  • Loratadine Impurity G (Methyl Loratadine)
  • Loratadine USP Related Compound B
  • N-METHYL DESLORATADINE
  • 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6] cyclohepta [1,2-b]pyridine (N-Methyl Desloratadine)
  • Methyl loratidine
  • 11- (N-Methyl-4-piperidinylidene)-8-chloro-6，11-dihydro-5H-benzo(5,6)cyclohepta (1,2-b) pyridine