ChemicalBook > CAS DataBase List > Cyclic AMP

Cyclic AMP

Product Name: Cyclic AMP
CAS No.: 60-92-4
Chemical Name: Cyclic AMP
Synonyms: CAMP;ADENOSINE CYCLOPHOSPHATE;Acrasin;ADENOSINE CYCLPHOSPHATE;(4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide;MRD40;C13orf8;3:5-CAMP;KIAA1802;Cyclo-AMP
CBNumber: CB8747868
Molecular Formula: C10H12N5O6P
Formula Weight: 329.21
MOL File: 60-92-4.mol

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Cyclic AMP Property

Melting point:: 260 °C (dec.)(lit.)
Boiling point:: 56.12°C
alpha: -53.7 º (c=0.7,water)
Density: 2.47±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: H₂O: 10 mg/mL pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20×
pka: 1.00±0.60(Predicted)
form: powder
color: white
biological source: mouse
Water Solubility: 50 mg/mL
Merck: 14,2708
BRN: 52645
Stability:: Hygroscopic
NIST Chemistry Reference: Adenosine 3',5'-cyclic monophosphate(60-92-4)
EPA Substance Registry System: Adenosine, cyclic 3',5'-(hydrogen phosphate) (60-92-4)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 22-24/25-45-36/37/39-26-36
WGK Germany: 3
RTECS: AU7357600
F: 10-21
TSCA: Yes
HS Code: 29349990
Toxicity: oms-hmn:oth 100 mmol/L JIDEAE 65,52,75

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9501
Product name: Adenosine 3′,5′-cyclic monophosphate
Purity: ≥98.5% (HPLC), powder
Packaging: 1g
Price: $303
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB5300171
Product name: Monoclonal Anti-cAMP antibody produced in mouse
Purity: clone 9H4C4, ascites fluid
Packaging: 100 μL
Price: $541
Updated: 2025/07/31

Sigma-Aldrich

Product number: A9501
Product name: Adenosine 3′,5′-cyclic monophosphate
Purity: ≥98.5% (HPLC), powder
Packaging: 5g
Price: $1150
Updated: 2025/07/31

TCI Chemical

Product number: A2381
Product name: Adenosine 3',5'-Cyclic Monophosphate Hydrate
Purity: >99.0%(HPLC)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: A2381
Product name: Adenosine 3',5'-Cyclic Monophosphate Hydrate
Purity: >99.0%(HPLC)
Packaging: 5g
Price: $274
Updated: 2025/07/31

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Cyclic AMP Chemical Properties,Usage,Production

Chemical Properties

White crystalline or Pale yellow powder; odorless. Slightly soluble in water, almost insoluble in ethanol or ether.

Uses

cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate.

Definition

ChEBI: Cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an adenyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).

Application

The chief role of cyclic AMP in several tissues seems to be to facilitate or promote the mobilization of glucose and fatty acid reserves. In the liver, glucagon and the catecholamines cause an increase in the intracellular level of cyclic AMPby stimulating adenyl cyclase. This increase in the level of .cyclic AMP leads to a net increase in hepatic glucose production by at least three mechanisms: stimulation of phosphorylase activation, suppression of glycogen synthetase activity, and stimulation of gluconeogenesis. The catecholamines also stimulate adenyl cyclase in muscle and adipose tissue. Among the principal effects of cyclic AMP in these tissues are glycogenolysis in muscle and lipolysis in adipose tissue.

General Description

Cyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways.

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Safety Profile

Human mutation data reported.When heated to decomposition it emits toxic fumes ofPOx and NOx.

Synthesis

Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell.[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs)-protein-coupled receptors. Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline.
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.

Cyclic AMP Preparation Products And Raw materials

Raw materials

Moroxydine Dicyclohexylcarbodide or CDCC Styrene cation exchange resin Anhydrous pyridine Water pump Ammonium bicarbonate Dicyclohexylcarbodiimide

Preparation Products

6-Thioguanine

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View Lastest Price from Cyclic AMP manufacturers

WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)

Product: Adenosine 3',5'-cyclic monophosphate (CAMP) 60-92-4
Price: US $0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 2tons
Release date: 2025-08-19

Wuhan JiyunZen Tech Co., Ltd.

Product: Cyclic AMP 60-92-4
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Adenosine Cyclophosphate 60-92-4
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 97%-103%
Supply Ability: 10kg
Release date: 2021-06-02

60-92-4, Cyclic AMPRelated Search:

phosphate ester starch Vidarabine monophosphate Clindamycin phosphate Adenosine Dibutyryl adenosine cyclophosphate calcium SULPHOSUCCINIC ACID ESTER ADP Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) ADENOSINE 5'-TRIPHOSPHATASE Adenosine 5'-monophosphate Adenosine 3',5'-cyclic monophosphate sodium salt Adenosine-5'-diphosphate disodium salt ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL& ADENOSINE 5'-DIPHOSPHATE MONOPOTASSIUM SALT Adenosine-5'-diphosphate trilithium salt ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 5'-Tosyladenosine ATP disodium salt

adenosine 3',5'-phosphate monohydrate

CAMP

CAMP, ADENOSINE-3',5'-CYCLIC MONOPHOSPHATE

CYCLIC AMP

CYCLIC AMP-3',5'

5’-cyclicmonophosphate

6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide

Acrasin

Adenosine 3',5'-cyclophosphate

Adenosine 3',5'-phosphate

Adenosine cyclic 3',5'-monophosphate

Adenosine cyclic 3',5'-phosphate

Adenosine cyclic monophosphate

Adenosine, cyclic 3',5'-(hydrogen phosphate)

adenosine,cyclic3’,5’-(hydrogenphosphate)

adenosine3’,5’-cyclophosphate

adenosine3’,5’-phosphate

adenosinecyclic3’,5’-phosphate

adenosinecyclicmonophosphate

adenosinecyclicphosphate,cyclicamp

Cyclic 3',5'-adenylic acid

Cyclic adenosine 3',5'-monophosphate

Cyclic adenosine 3',5'-phosphate

cyclic3’,5’-(hydrogenphosphate)-adenosin

ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE*HPL C MARKER

ADENOSINE 3':5'-CYCLIC MONOPHOSPHATEFREE ACID

(-)-ADENOSIN-3',5'-CYCLOPHOSPHORSAEURE 9

ADENOSINE CYCLPHOSPHATE

Adenosine 3',5'-hydrogen phosphate

Adenosine 3'-,5'-cyclic monophosphate, 99+%

Adenosine-3’,5’-cyclic phosphoric acid

cyclic 3',5'-(hydrogen phosphate)Adenosine

Adenosine-3'',5''-monophosphoric acid

CYCLIC-AMP (ADENOSINE 3'', 5''-CYCLIC MONOPHOSPHATE)

ADENOSINE-3,5-CYCLICMONOPHOSPHPRIC ACID extrapure for biochemistry

3μ,5μ-Cyclic AMP, Adenosine 3μ,5μ-cyclophosphate, cAMP

Cyclic Adenosine Monophosphate (cAMP)

3',5'-cAMP Hydrate

cyclic3’,5’-adenylicacid

cyclic3’,5’-amp

cyclicadenosine3’,5’-phosphate

(S)-CYCLIC 3' 5'-(HYDROGEN PHOSPHATE) ADENOSINE

ADENOSINE CYCLICPHOSPHATE

ADENOSINE CYCLOPHOSPHATE

(-)-ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE

ADENOSINE 3'-,5'-CYCLIC MONOPHOSPHATE

ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE

ADENOSINE-3',5'-CYCLIC-MONOPHOSPHORIC ACID

ADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID

ADENOSINE-3':5'-CYCLIC PHOSPHATE

ADENOSINE-3',5'-CYCLIC PHOSPHATE H2O

ADENOSINE-3',5'-CYCLOPHOSPHORIC ACID

ADENOSINE 3'5'-MONOPHOSPHATE

ADENOSINE-3':5'-PHOSPHATE CYCLIC

3:5-CAMP

3',5'-Cyclic adenylphosphoric acid

Adenosine-3',5'-cyclophosphate ,99%

Adenosine 3',5'-Cyclic Monophosphate Hydrate