SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH

Product Name: SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH
CAS No.: 131791-98-5
Chemical Name: SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH
Synonyms: Suc-F-E-P-I-P-E-Glu-Tyr(OSO3H)-L-DGlu;SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU;SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED);SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH;Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH;D-Glutamic acid,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]-;D-Glutamic acid, N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- (9CI)
CBNumber: CB8752215
Molecular Formula: C64H88N10O26S
Formula Weight: 1445.5
MOL File: 131791-98-5.mol

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SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Property

Density: 1.413±0.06 g/cm3(Predicted)
storage temp.: -15°C
pka: -4.17±0.18(Predicted)
Sequence: {Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu}

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Hazard and Precautionary Statements (GHS)

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SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Chemical Properties,Usage,Production

Uses

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].

References

[1] Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. DOI:10.1006/jmbi.1999.3178
[2] Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7. DOI:10.1021/jm00107a043

SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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131791-98-5, SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OHRelated Search:

SUC-ALA-ALA-PRO-LYS-PNA succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide SUC-ALA-ALA-PRO-ASP-PNA SUC-ALA-ILE-PRO-PHE-PNA SUC-GLY-PHE-GLY-PNA CHYMOTRYPSIN SUBSTRATE I, COLORIMETRIC SUC-ALA-ALA-PRO-VAL-AMC Chymotrypsin Substrate II, Fluorogenic SUC-ALA-PRO-PNA SUC-ALA-PHE-LYS-AMC SUC-PHE-PRO-PHE-PNA SUC-ALA-VAL-PRO-PHE-PNA SUC-ALA-GLU-PRO-PHE-PNA Suc-Phe-Gly-Leu-βNA SUC-PHE-ALA-ALA-PHE-PNA SUC-ALA-ALA-VAL-AMC SUC-ALA-ALA-PRO-NVA-PNA SUC-VAL-PRO-PHE-SBZL

SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED)

SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU

SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH

Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH

D-Glutamic acid,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]-

D-Glutamic acid, N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- (9CI)

Suc-F-E-P-I-P-E-Glu-Tyr(OSO3H)-L-DGlu

131791-98-5

C64H86N10O25S