ChemicalBook > CAS DataBase List > Toloxatone

Toloxatone

Product Name
Toloxatone
CAS No.
29218-27-7
Chemical Name
Toloxatone
Synonyms
Humoryl;69276MD;Perenum;MD-69276;Toloxatone;Taloxotone;Delalande 69276;Toloxatone USP/EP/BP;Toloxatone - MD 69276;Toloxatone, 10 mM in DMSO
CBNumber
CB8752750
Molecular Formula
C11H13NO3
Formula Weight
207.23
MOL File
29218-27-7.mol
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Toloxatone Property

Melting point:
76°
Boiling point:
358.9±21.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
14.05±0.10(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
3249
WGK Germany 
3
RTECS 
RQ2867500
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orally in mice (mg/kg): 1850 (Fauran); also reported as 1500 (Raynaud)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3452
Product name
Toloxatone
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$104
Updated
2025/07/31
Sigma-Aldrich
Product number
T3452
Product name
Toloxatone
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$468
Updated
2025/07/31
Usbiological
Product number
467706
Product name
Toloxatone
Packaging
10mg
Price
$340
Updated
2021/12/16
TRC
Product number
T537005
Product name
Toloxatone
Packaging
250mg
Price
$1865
Updated
2021/12/16
ChemScene
Product number
CS-0002916
Product name
Toloxatone
Purity
99.34%
Packaging
5mg
Price
$60
Updated
2021/12/16
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Toloxatone Chemical Properties,Usage,Production

Description

Toloxatone is a selective, reversible and competitive inhibitor of type A monoamine oxidase (MAO-A) which shows clinical utility as an antidepressant. It is reportedly free of the "cheese effect" in man, possibly due to the reversible nature of its inhibitory effect on intestinal MAO-A in the presence of high concentrations of tyramine.

Chemical Properties

Crystallized from isopropyl alcohol, melting point 76°C. Acute toxicity LD50 in mice (mg/kg): 1850 or 1500 oral.

Originator

Delalande (France)

Uses

Toloxatone is a monoamine oxidase-A (MAO-A) inhibitor.

Definition

ChEBI: 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one is a member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3. It is a member of toluenes, an oxazolidinone and a primary alcohol.

brand name

HUMORYL

Toloxatone Preparation Products And Raw materials

Raw materials

m-Toluidine Methyl chloroformate Propylene glycol Propylene oxide

Preparation Products

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Toloxatone Suppliers

China 45 Germany 1 United Kingdom 2 United States 12 Global 60
Shanghai Lollane Biological Technology Co.,Ltd.
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ShangHai Biochempartner Co.,Ltd
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8000
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Shanghai SuperLan Chemcial Technique Centre
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Amadis Chemical Company Limited
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View Lastest Price from Toloxatone manufacturers

Dideu Industries Group Limited
Product
Toloxatone 29218-27-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26

29218-27-7, ToloxatoneRelated Search:

Duloxetine Toloxatone HYDROXYPROPYLCARBAMATE 2-Oxazolidinone, 5-hydroxymethyl-3-(m-tolyl)-, carbamate 3-PHENYL-2-OXAZOLIDINONE

  • 2-OXAZOLIDINONE, 5-(HYDROXYMETHYL)-3-(3-METHYLPHENYL)-
  • Toloxatone
  • ToloxatonetoloxatonetoloxatoneToloxatone
  • 5-Hydroxymethyl-3-(3-methylphenyl)oxazolidin-2-one
  • Humoryl
  • MD-69276
  • Perenum
  • 5-(Hydroxymethyl)-3-(m-tolyl)oxazolidin-2-one
  • 5-Hydroxymethyl-3-(m-tolyl)oxazolidin-2-one
  • 69276MD
  • Delalande 69276
  • Taloxotone
  • 5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone
  • Toloxatone - MD 69276
  • Toloxatone USP/EP/BP
  • Toloxatone,Monoamine Oxidase,MD69276,MD-69276,MAO,inhibit,Inhibitor
  • Toloxatone, 10 mM in DMSO
  • 29218-27-7