ChemicalBook > CAS DataBase List > m-Toluidine

m-Toluidine

Product Name
m-Toluidine
CAS No.
108-44-1
Chemical Name
m-Toluidine
Synonyms
m-Toluidin;m-Toludine;m-Toluidiue;m-toluidyna;3-Toluidine;M-TOLUIDINE;m-Toluamine;m-Tolylamine;M-Toluidine 0;3-Aminotoluen
CBNumber
CB4277541
Molecular Formula
C7H9N
Formula Weight
107.15
MOL File
108-44-1.mol
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m-Toluidine Property

Melting point:
-30 °C
Boiling point:
203-204 °C(lit.)
Density 
0.999 g/mL at 25 °C(lit.)
vapor pressure 
0.3 hPa (20 °C)
refractive index 
n20/D 1.567(lit.)
Flash point:
186 °F
storage temp. 
Store below +30°C.
solubility 
0.2 g/100 mL (20°C)
pka
4.73(at 25℃)
form 
Crystalline Solid or Liquid
color 
White
PH
7 (H2O, 20℃)
Water Solubility 
0.2 g/100 mL (20 ºC)
Merck 
14,9536
BRN 
635944
Exposure limits
TLV-TWA skin 2-ppm (~9 mg/m3) (ACGIH).
InChIKey
JJYPMNFTHPTTDI-UHFFFAOYSA-N
CAS DataBase Reference
108-44-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3-methyl-(108-44-1)
EPA Substance Registry System
m-Toluidine (108-44-1)
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Safety

Hazard Codes 
T,N
Risk Statements 
45-23/24/25-33-50
Safety Statements 
53-28-36/37-45-61-28A
RIDADR 
UN 1708 6.1/PG 2
WGK Germany 
2
RTECS 
XU2800000
8-23
Autoignition Temperature
>500 °C
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29171990
HS Code 
29214300
Hazardous Substances Data
108-44-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H311Toxic in contact with skin

H319Causes serious eye irritation

H331Toxic if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
511218
Product name
m-Toluidine
Purity
99%
Packaging
5ml
Price
$22.8
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08314
Product name
m-Toluidine
Purity
for synthesis
Packaging
100 mL
Price
$28.58
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08314
Product name
m-Toluidine
Purity
for synthesis
Packaging
1 L
Price
$78.44
Updated
2021/12/16
Sigma-Aldrich
Product number
511218
Product name
m-Toluidine
Purity
99%
Packaging
1l
Price
$115
Updated
2021/12/16
Sigma-Aldrich
Product number
511218
Product name
m-Toluidine
Purity
99%
Packaging
100ml
Price
$28.2
Updated
2021/03/22
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m-Toluidine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid. Slightly soluble in water; soluble in alcohol or ether. Combustible.

Uses

Dyes, manufacture of organic chemicals.

Uses

m-Toluidine is an intermediate in the manu facture of dyes and other chemicals.

Uses

m-Toluidine is used in the manufacture of organic chemicals. It is also used in manufacture of various dyes and pigments, photo chemicals, pharmaceutical intermediates.antioxidants, curing agent, accelerator for polymer and rubber industry.

Synthesis Reference(s)

Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749

General Description

A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.

Reactivity Profile

m-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

The toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.

Safety Profile

Poison by ingestion and intraperitoneal routes, A skin and eye irritant. Flammable when exposed to heat or flame. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx. See also ANILINE and o-TOLUIDINE.

Carcinogenicity

In an 18-month carcinogenicity diet evaluation in maleCD rats (8000 ppm for 3 months, and then 4000 ppm for additional 15 months; or 16,000 ppm for 3 months, and then 8000 for additional 15 months), and male and female CD-1 mice (16,000 ppm for 5 months, and then 4000 ppm in males and 8000 ppm in females for additional 13 months; or 32,000 ppm in both sexes for 5 months, and then 8000 ppm in males and 16,000 ppm in females for additional 13 months), there was no evidence of a significant increase of incidence of any kind of tumor in the rats, and only a significant increase in liver tumors in male mice.

Purification Methods

It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]

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m-Toluidine Suppliers

Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43430
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35909
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12270
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
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View Lastest Price from m-Toluidine manufacturers

Hebei Crovell Biotech Co Ltd
Product
3-METHYLBENZENAMINE 108-44-1
Price
US $4.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2021-07-05
Hebei Guanlang Biotechnology Co., Ltd.
Product
m-Toluidine 108-44-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-28
Career Henan Chemical Co
Product
m-Toluidine 108-44-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

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