Methyl coumalate

Product Name: Methyl coumalate
CAS No.: 6018-41-3
Chemical Name: Methyl coumalate
Synonyms: METHYL 2-OXO-2H-PYRAN-5-CARBOXYLATE;Coumalic acid methyl ester;Methyl coumaric acid;METHYL COUMALATE;TIMTEC-BB SBB000117;Methyl coumalate 98%;Methyl Coumalate >5-(Carbomethoxy)-2-pyrone;Methyl 2-pyrone-5-carboxylate;METHYL PYR-2-ONE-5-CARBOXYLATE
CBNumber: CB8755382
Molecular Formula: C7H6O4
Formula Weight: 154.12
MOL File: 6018-41-3.mol

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Methyl coumalate Property

Melting point:: 65-67 °C (lit.)
Boiling point:: 178-180 °C/60 mmHg (lit.)
Density: 1.1993 (rough estimate)
refractive index: 1.4300 (estimate)
Flash point:: 178-180°C/60mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Freely soluble in dichloromethane.
form: powder to crystal
color: White to Orange to Green
Merck: 14,2557
BRN: 126301
LogP: -0.660 (est)
CAS DataBase Reference: 6018-41-3(CAS DataBase Reference)
NIST Chemistry Reference: 2H-Pyran-5-carboxylic acid, 2-oxo-, methyl ester(6018-41-3)

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Safety

WGK Germany: 3
HS Code: 2932209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 261432
Product name: Methyl coumalate
Purity: 98%
Packaging: 10g
Price: $441
Updated: 2024/03/01

TCI Chemical

Product number: C1734
Product name: Methyl Coumalate
Purity: >96.0%(GC)
Packaging: 5g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: C1734
Product name: Methyl Coumalate
Purity: >96.0%(GC)
Packaging: 25g
Price: $278
Updated: 2024/03/01

Alfa Aesar

Product number: B25330
Product name: Methyl coumalate, 98%
Packaging: 2g
Price: $47.65
Updated: 2024/03/01

Alfa Aesar

Product number: B25330
Product name: Methyl coumalate, 98%
Packaging: 10g
Price: $165.65
Updated: 2024/03/01

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Methyl coumalate Chemical Properties,Usage,Production

Uses

α, β-Unsaturated ketone Methyl Coumalate showed cytotoxicity against human normal gingival fibroblast cells and oral squamous cell carcinoma cell line-2.

Uses

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.02,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts. It has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

Uses

Methyl coumalate has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

General Description

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.0^2,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts.

Methyl coumalate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl coumalate Suppliers

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View Lastest Price from Methyl coumalate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Methyl coumalate 6018-41-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-21

Guangzhou Sunton Biotechnology Co., Ltd.

Product: Methyl coumaric acid 6018-41-3
Price: US $48.00-40.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons
Release date: 2021-06-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl coumalate 6018-41-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

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METHYL 2H-PYRAN-2-OXO-5-CARBOXYLATE

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Methyl coumaric acid

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Methyl coumalate ISO 9001：2015 REACH

6018-41-3

25898-60-7

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