2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 885278-75-1
- Chemical Name
- 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-(4-bromophenyl)thiazole-4-carboxylate;Ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate;4-THIAZOLECARBOXYLICACID, 2-(4-BROMOPHENYL)-, ETHYL ESTER;2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB8755544
- Molecular Formula
- C12H10BrNO2S
- Formula Weight
- 312.18
- MOL File
- 885278-75-1.mol
2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 89-91 °C
- Boiling point:
- 404.6±51.0 °C(Predicted)
- Density
- 1.500±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.42±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- B698715
- Product name
- 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B698715
- Product name
- 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B698715
- Product name
- 2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB56451
- Product name
- 2-(4-Bromophenyl)thiazole-4-carboxylic acid ethyl ester
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- W9103
- Product name
- Ethyl2-(4-bromophenyl)thiazole-4-carboxylate
- Packaging
- 5g
- Price
- $181
- Updated
- 2021/12/16
2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
70-23-5
26197-93-3
885278-75-1
The general procedure for the synthesis of ethyl 2-(4-bromophenyl)-thiazole-4-carboxylate from ethyl 3-bromopyruvate and 4-bromothiobenzamide is as follows: (i) Ethyl 3-bromopyruvate (0.18 mL, 1.0 mmol) was slowly added to an ethanol solution (3 mL) of 4-bromothiobenzamide (529 mg, 1.0 mmol). (ii) The reaction mixture was stirred at room temperature for 6 h. The precipitated crystals were subsequently collected by filtration and dried. (iii) The dried crystals were slowly added dropwise to concentrated sulfuric acid (5 mL) and stirred at room temperature for 3 hours. (iv) The solvent was removed by distillation and the residue was diluted with ethyl acetate. (v) The diluted solution was washed sequentially with saturated aqueous sodium bicarbonate and deionized water, and the organic layer was dried with anhydrous magnesium sulfate. (vi) After filtration, the filtrate was concentrated and the resulting crystals were collected by filtration and dried to afford ethyl 2-(4-bromophenyl)-thiazole-4-carboxylate (285 mg, 91% yield). Product characterization data: 1H-NMR (300 MHz, CDCl3) δ: 1.30 (3H, t, J = 7.5 Hz), 4.30 (1H, q, J = 7.5 Hz), 7.65 (2H, d, J = 7.8 Hz), 7.85 (2H, d, J = 7.8 Hz), 8.15 (1H, s). MS (FAB) m/z: 313 (M+ +1).
References
[1] Patent: EP2166015, 2010, A1. Location in patent: Page/Page column 25
[2] European Journal of Inorganic Chemistry, 2015, vol. 2015, # 29, p. 4935 - 4945
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1545 - 1555
[4] Medicinal Chemistry Research, 2016, vol. 25, # 10, p. 2399 - 2409
[5] Research on Chemical Intermediates, 2018, vol. 44, # 2, p. 1247 - 1260
2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 885278-75-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31