2,6-DIAMINO-4-METHYL PYRIDINE
- Product Name
- 2,6-DIAMINO-4-METHYL PYRIDINE
- CAS No.
- 38439-33-7
- Chemical Name
- 2,6-DIAMINO-4-METHYL PYRIDINE
- Synonyms
- Fampridine Impurity 32;4-Methyl-2,6-pyridinediamine;4-METHYLPYRIDINE-2,6-DIAMINE;2,6-PyridinediaMine,4-Methyl-;2,6-DIAMINO-4-METHYL PYRIDINE;2,6-DIAMINO-4-METHYL PYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB8755706
- Molecular Formula
- C6H9N3
- Formula Weight
- 123.16
- MOL File
- 38439-33-7.mol
2,6-DIAMINO-4-METHYL PYRIDINE Property
- Melting point:
- 85-86 °C
- Boiling point:
- 312.5±37.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 6.79±0.35(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M329075
- Product name
- 4-Methylpyridine-2,6-diamine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- M329075
- Product name
- 4-Methylpyridine-2,6-diamine
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FD151013
- Product name
- 2,6-Diamino-4-methylpyridine
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FD151013
- Product name
- 2,6-Diamino-4-methylpyridine
- Packaging
- 100mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- FD151013
- Product name
- 2,6-Diamino-4-methylpyridine
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
2,6-DIAMINO-4-METHYL PYRIDINE Chemical Properties,Usage,Production
Uses
4-Methylpyridine-2,6-diamine is a reactant in the preparation of N-(pyridin-2-yl) arylsulfonamides with potent 11β-hydroxysteroid dehydrogenase type 1 activity.
Synthesis
108-89-4
38439-33-7
General procedure for the synthesis of 2,6-diamino-4-methylpyridine from 4-methylpyridine: General method: synthesis of 4-methylpyridine-2,6-diamine (1). Method A: 4-Methylpyridine (15 g, 161.1 mmol) was suspended in mineral oil (220 mL), sodium amide (27.0 g, 483.3 mmol, 3 eq.) was added and stirred overnight at room temperature. Subsequently, the homogeneous suspension was heated to 130 °C and maintained for 15 min, and the beginning of hydrogen precipitation was observed. The temperature was gradually increased to 160 °C over 30 min, the color of the suspension changed from light brown to dark brown and the mixture formed a foamy solid. Continuing heating to 200 °C over 30 min, hydrogen release accelerated and the color of the mixture changed to black. After 3 hours of reaction at 215 °C, complete consumption of the feedstock and completion of hydrogen release was confirmed by TLC (unfolding agent: ethyl acetate/methanol/acetic acid, 10:1:0.1) monitoring. The reaction mixture was cooled to room temperature, the black solid was collected by filtration and washed with petroleum ether (5 x 100 mL). Silica gel (100 g) and 96% ethanol (130 mL) were carefully added to the black solid and evaporated to dryness after 20 min. Subsequently, the solid was placed on top of a suction filter containing silica gel (300 g; ethyl acetate) and eluted using a gradient of ethyl acetate to ethyl acetate/isopropanol (8:1), the product grade was collected and evaporated. The brown residue was recrystallized with tert-butyl methyl ether/diisopropyl ether to give 13.1 g of target product 1 as gray crystals in 66% yield. Method B: The compound was prepared by a similar method to 1 using 2-amino-4-methylpyridine (15 g, 138.7 mmol) and sodium amide (16.2 g, 416.1 mmol, 3 equiv) as starting materials. Yield: 13.2 g (76%). Melting point: 100-102 °C. 1H NMR (DMSO-d6) δ: 5.46 (s, 2H, pyridine ring H), 5.21 (s, 4H, NH2), 1.95 (s, 3H, CH3). 13C{1H} NMR (DMSO-d6) δ: 158.7 (pyridine ring C), 148.1 (pyridine ring C), 96.2 (pyridine ring C). 20.7 (CH3).HRMS (ESI):[M + H]+, measured value 124.0869.Theoretically calculated value 124.0875 for C6H9N3.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 333 - 336
[2] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6513 - 6522
[3] Journal of the American Chemical Society, 2015, vol. 137, # 25, p. 7998 - 8001
[4] Patent: WO2006/106423, 2006, A2. Location in patent: Page/Page column 29
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 1147,1148
2,6-DIAMINO-4-METHYL PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-DIAMINO-4-METHYL PYRIDINE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 2,6-DIAMINO-4-METHYL PYRIDINE manufacturers
- Product
- 4-Methyl-2,6-pyridinediamine 38439-33-7
- Price
- US $8.80-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2025-09-16
- Product
- 2,6-diamino-4-methylpyridine 38439-33-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-24
- Product
- 2,6-DIAMINO-4-METHYL PYRIDINE 38439-33-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25