ChemicalBook > CAS DataBase List > 4-(Trifluoromethyl)benzophenone

4-(Trifluoromethyl)benzophenone

Product Name
4-(Trifluoromethyl)benzophenone
CAS No.
728-86-9
Chemical Name
4-(Trifluoromethyl)benzophenone
Synonyms
11β-HSD1-IN-7;Phenyl(4-(trifluoromethyl);P-TRIFLUOROMETHYL BENZOPHENONE;4'-Trifluoromethylbenzophenone;4-(TRIFLUOROMETHYL)BENZOPHENONE;4-(Trifluoromethyl)benzophenone97%;4-(TRIFLUOROMETHYL)BENZOPHENONE 97%;4-(Trifluoromethyl)benzophenone, 98+%;Phenyl[4-(trifluoromethyl)phenyl] ketone;PHENYL[4-(TRIFLUOROMETHYL)PHENYL]METHANONE
CBNumber
CB8765628
Molecular Formula
C14H9F3O
Formula Weight
250.22
MOL File
728-86-9.mol
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4-(Trifluoromethyl)benzophenone Property

Melting point:
114-116 °C(lit.)
Boiling point:
309.2±42.0 °C(Predicted)
Density 
1.2778 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Solid
color 
Off-white to beige
BRN 
1879572
InChI
InChI=1S/C14H9F3O/c15-14(16,17)12-8-6-11(7-9-12)13(18)10-4-2-1-3-5-10/h1-9H
InChIKey
OHTYZZYAMUVKQS-UHFFFAOYSA-N
SMILES
C(C1=CC=CC=C1)(C1=CC=C(C(F)(F)F)C=C1)=O
CAS DataBase Reference
728-86-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T797060
Product name
4-(Trifluoromethyl)benzophenone
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0022414
Product name
4-(TRIFLUOROMETHYL)BENZOPHENONE
Purity
95.00%
Packaging
5G
Price
$779.86
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0022414
Product name
4-(TRIFLUOROMETHYL)BENZOPHENONE
Purity
95.00%
Packaging
25G
Price
$1148.65
Updated
2021/12/16
Apolloscientific
Product number
PC7570
Product name
4-(Trifluoromethyl)benzophenone
Purity
97%
Packaging
25g
Price
$73
Updated
2021/12/16
SynQuest Laboratories
Product number
2817-3-34
Product name
4-(Trifluoromethyl)benzophenone
Purity
98%
Packaging
25g
Price
$115
Updated
2021/12/16
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4-(Trifluoromethyl)benzophenone Chemical Properties,Usage,Production

Chemical Properties

OFF-WHITE TO BEIGE CRYSTALLINE SOLID

Uses

11β-HSD1-IN-7 (compound c10a) is a 11β HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline[1].

Synthesis

A solution of diphenylmethanol (1 mmol), NBS (1.3equiv.), KOAc (1.5 equiv.) H2O (1.5 mL), and CH2Cl2 (0.5mL) was magnetically stirred in 25 mL flask at room temperaturefor 10 h. The reaction mixture was added into water(10 mL), and extracted with EtOAc (3 × 10 mL). The combinedEtOAc extracts were dried over anhydrous MgSO4,filtrated, and then the solvent was removed under reducedpressure. The residue was purified by the flash columnchromatography on silica gel with PE or PE/EtOAc as theeluent to obtain the desired product 4-(Trifluoromethyl)benzophenone.

References

[1] Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. DOI:10.1038/s41598-022-18740-5

4-(Trifluoromethyl)benzophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethyl)benzophenone Suppliers

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View Lastest Price from 4-(Trifluoromethyl)benzophenone manufacturers

Speranza Chemical Co., Ltd.
Product
4-(Trifluoromethyl)benzophenone 728-86-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100MT/Year
Release date
2024-11-07

728-86-9, 4-(Trifluoromethyl)benzophenoneRelated Search:

2-FLUORO-4-(TRIFLUOROMETHYL)BENZOPHENONE,2-Fluoro-4-(trifluoromethyl)benzophenone97%,2-Fluoro-4-(trifluoromethyl)benzophenone 97% 4-(Trifluoromethyl)benzophenone 3-FLUORO-4-(TRIFLUOROMETHYL)BENZOPHENONE 3,4'-Bis(trifluoromethyl)benzophenone98%,3,4'-BIS(TRIFLUOROMETHYL)BENZOPHENONE,3,4'-DI(TRIFLUOROMETHYL)BENZOPHENONE,3,4'-Bis(trifluoromethyl)benzophenone 98% 2-(TRIFLUOROMETHYL)BENZOPHENONE,2-(Trifluoromethyl)benzophenone98%,2-(TRIFLUOROMETHYL)BENZOPHENONE 99% 4-FLUORO-3-(TRIFLUOROMETHYL)BENZOPHENONE 3-(Trifluoromethyl)benzophenone98%,3-(TRIFLUOROMETHYL)BENZOPHENONE,3-(TRIFLUOROMETHYL)BENZOPHENONE 99% 3,3',5,5'-Tetrakis(trifluoromethyl)benzophenone 97%,3,3',5,5'-TETRAKIS(TRIFLUOROMETHYL)BENZOPHENONE,3,3',5,5'-Tetrakis(trifluoromethyl)benzophenone97% 2-Fluoro-6-(trifluoromethyl)benzophenone97%,2-FLUORO-6-(TRIFLUOROMETHYL)BENZOPHENONE 3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE, 9 8%,3,3'-Bis(trifluoromethyl)benzophenone 98%,3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE,3,3'-DI(TRIFLUOROMETHYL)BENZOPHENONE 2,2'-DICHLORO-5,5'-BIS-TRIFLUOROMETHYL-BENZOPHENONE 3-FLUORO-5-(TRIFLUOROMETHYL)BENZOPHENONE 2-Chloro-5-(trifluoromethyl)benzophenone 97%,2-Chloro-5-(trifluoromethyl)benzophenone97%,2-CHLORO-5-(TRIFLUOROMETHYL)BENZOPHENONE 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOPHENONE,2-Fluoro-3-(trifluoromethyl)benzophenone 97%,2-Fluoro-3-(trifluoromethyl)benzophenone97% 2-Fluoro-5-(trifluoromethyl)benzophenone 97%,2-FLUORO-5-(TRIFLUOROMETHYL)BENZOPHENONE,2-Fluoro-5-(trifluoromethyl)benzophenone97% 3,5-Bis(trifluoromethyl)benzophenone 97%,3,5-BIS(TRIFLUOROMETHYL)BENZOPHENONE,3,5-DI(TRIFLUOROMETHYL)BENZOPHENONE Benzophenone METHOXYPHENONE

  • 4-(TRIFLUOROMETHYL)BENZOPHENONE
  • 4-(TRIFLUOROMETHYL)BENZOPHENONE 97%
  • 4-(Trifluoromethyl)benzophenone97%
  • 4-(Trifluoromethyl)benzophenone, 98+%
  • Phenyl[4-(trifluoromethyl)phenyl] ketone
  • Phenyl(4-(trifluoromethyl)
  • Methanone, phenyl[4-(trifluoromethyl)phenyl]-
  • PHENYL[4-(TRIFLUOROMETHYL)PHENYL]METHANONE
  • P-TRIFLUOROMETHYL BENZOPHENONE
  • (4-(trifluoromethyl)phenyl)(phenyl)methanone
  • 11β-HSD1-IN-7
  • 4'-Trifluoromethylbenzophenone
  • 728-86-9
  • CF3C6H4COC6H5
  • C14H9F3O
  • Ketones
  • KETONE
  • Building Blocks
  • Carbonyl Compounds
  • C13 to C14
  • Organic Building Blocks