PROTEASOME INHIBITOR I

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PROTEASOME INHIBITOR I

Product Name: PROTEASOME INHIBITOR I
CAS No.: 158442-41-2
Chemical Name: PROTEASOME INHIBITOR I
Synonyms: PSI;N-Cb;CS-1340;Z-IE(OTBU)AL-CHO;PROTEASOME INHIBITOR I;ProteasoMe Inhibitor 1;PROTEASOME INHIBITOR PSI;M.W. 618.77 C32H50N4O8;Z-ILE-GLU(OBUT)-ALA-LEU-H;Z-ILE-GLU(OTBU)-ALA-LEU-CHO
CBNumber: CB8781378
Molecular Formula: C32H50N4O8
Formula Weight: 618.76
MOL File: 158442-41-2.mol

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PROTEASOME INHIBITOR I Property

Boiling point:: 844.2±65.0 °C(Predicted)
Density: 1.121±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥48.7 mg/mL in EtOH
form: solid
pka: 11.12±0.46(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 539160
Product name: Proteasome Inhibitor I
Purity: The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging: 1MG
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 539160
Product name: Proteasome Inhibitor I
Purity: The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging: 5MG
Price: $360
Updated: 2024/03/01

Usbiological

Product number: 256358
Product name: PSI
Packaging: 5mg
Price: $480
Updated: 2021/12/16

TRC

Product number: P838815
Product name: ProteasomeInhibitor1
Packaging: 100mg
Price: $4675
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 66848
Product name: ProteasomeInhibitor1
Packaging: 100mg
Price: $5250
Updated: 2021/12/16

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PROTEASOME INHIBITOR I Chemical Properties,Usage,Production

Uses

Proteasome Inhibitor 1, is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It is also shown to be used for the treatment of cancer, especially multiple myeloma. Proteasome inhibitors also induce apoptosis and reduce viral replication in primary effusion lymphoma cells.

Biological Activity

zie(otbu)al-cho (psi)1 have been shown to inhibit the proteasome activities in a variety of cell types.peptide aldehyde, psi (z-ile-glu(otbu)-ala-leu-al), inhibits the proteasome 10-fold better than calpain but is less potent than mg1322. since mg132, psi, mg115 (z-leu-leu-nval-al) and alln can all inhibit calpains and various lysosomal cathepsins in addition to the proteasome, when using these inhibitors in cell culture it is important to perform control experiments to con¢rm that the observed e¡ects are due to the inhibition of the proteasome. first, one can use agents, which block intracellular cysteine proteases, but do not inhibit proteasomes3. such inhibitors are z-leu-leu- al, and e-64 for calpains4, and weak bases such as chloroquine and e-64 for lysosomal proteolysis . in yeast, where digestive vacuoles contain mainly serine, not cysteine, proteases, phenylmethylsulfonyl £uoride can be used to inhibit these enzymes without affecting proteasomes5.despite the availability of these inhibitors, mg132, due to its low cost and the rapid reversibility of its action, still remains, in our opinion, the first choice to study proteasome involvement in a process in cell cultures or tissues, if appropriate controls are used. as the most potent and selective of commercially available aldehydes, mg132 is preferable to alln, mg115 (z-leu-leu-nval-al), or even psi. on the other hand, the least selective inhibitor, alln, because of its ability to inhibit most major pro teases in mammalian cells, is probably the best tool for prevention of unwanted proteolysis, for example during isolation of proteins from mammalian cells.

References

1. takada k (1995) mol. biol. rep. 21: 21–26 2. a. f. kisselev, a. l. goldberg. proteasome inhibitors: from research tools to drug candidates. chemistry & biology 8 (2001) 739-758. 3. w. matthews, j. driscoll, k. tanaka, a. ichihara, a.l. goldberg, involvement of the proteasome in various degradative processes in mammalian cells, proc. natl. acad. sci. usa 86 (1989) 2597-2601. 4. s. tsubuki, y. saito, m. tomioka, h. ito, s. kawashima, differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine, j. biochem. 119 (1996) 572-576. 5. d.h. lee, a.l. goldberg, selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in saccharomyces cerevisiae, j. biol. chem. 271 (1996) 27280-27284.

PROTEASOME INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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158442-41-2, PROTEASOME INHIBITOR IRelated Search:

CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL

BENZYLOXYCARBONYL-L-ISOLEUCYL-[(2S)-2-AMINO-4-(T-BUTYLOXYCARBONYL)BUTANOYL]-L-ALANYL-L-LEUCINAL

PROTEASOME INHIBITOR I

PROTEASOME INHIBITOR I (ALDEHYDE)

PROTEASOME INHIBITOR PSI

PSI

N-CBZ-ILE-GLU(O-T-BUTYL)-ALA-LEUCINAL

Z-IE(OTBU)AL-CHO

Z-ILE-GLU(OBUT)-ALA-LEU-H

Z-ILE-GLU(OBUT)-ALA-LEU-H (ALDEHYDE)

Z-ILE-GLU(OTBU)-ALA-LEU-ALDEHYDE

Z-ILE-GLU(OTBU)-ALA-LEU-CHO

z-ile-glu(o-t-butyl)-ala-leucinal

Z-ILE-GLU(OTBU)-ALA-LEUCINAL

N-carbobenzyloxy-Ile-Glu(O-tert-butyl)-Ala-leucinal

M.W. 618.77 C32H50N4O8

arbobenzoxy-l-isoleucyl-gamma-t-butyl-l-glutamyl-l-alanyl-l-leucinal

N-Cb

L-AlaninaMide, N-[(phenylMethoxy)carbonyl]-L-isoleucyl-L-a-glutaMyl-N-[(1S)-1-forMyl-3 -Methylbutyl]-, 1,1-diMethylethyl ester

ProteasoMe Inhibitor 1

PSI PROTEASOME INHIBITOR I

N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide

PROTEASOME INHIBITOR I ;Z-ILE-GLU(OTBU)-ALA-LEU-CHO

CS-1340

L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester

PROTEASOME INHIBITOR I USP/EP/BP

Cbz-Ile-Glu(OtBu)-Ala-Leu-al

CBZ-Ile-Glu(OtBu)-Ala-Leu-aldehyde

N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide

HBL6 cells,Inhibitor,apoptosis,PSI,Proteasome Inhibitor1,Proteasome Inhibitor 1,Primary effusion lymphoma (PEL),BC3 cells,KSHV,inhibit,Proteasome Inhibitor-1,NF-κB,Proteasome

158442-41-2

C32H50N4O8

Calpain and Proteasome Inhibitors

Intracellular Protein Degradation

Nitric Oxide and Cell Stress

Caspases/Apoptosis

Calpain and Proteasome Inhibitors

Intracellular Protein Degradation

Aldehydes

Bioactive Small Molecules

Building Blocks

C13-C60

Carbonyl Compounds

Cell Biology

Cell Signaling and Neuroscience

Chemical Synthesis

Nitric Oxide and Cell Stress

Organic Building Blocks

Pepetides

ProteasomeInhibitors

peptides