FIDAS-3
- Product Name
- FIDAS-3
- CAS No.
- 1266684-01-8
- Chemical Name
- FIDAS-3
- Synonyms
- FIDAS-3;FIDAS-3 ，E0081;FIDAS-3, 10 mM in DMSO;Wnt Pathway Inhibitor XII;(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline;Benzenamine, 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-;FIDAS-3,Inhibitor,Wnt,CyclinD1,anti-proliferation,FIDAS3,FIDAS 3,c-Myc,MAT2A,β-catenin,S-adenosylmethionine,anti-cancer,SAH,inhibit,SAM
- CBNumber
- CB88054403
- Molecular Formula
- C16H15F2N
- Formula Weight
- 259.29
- MOL File
- 1266684-01-8.mol
FIDAS-3 Property
- Boiling point:
- 355.8±30.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 100 mg/mL (385.67 mM; Need ultrasonic)
- form
- A solid
- pka
- 4.68±0.24(Predicted)
- color
- off-white to pale yellow
FIDAS-3 Chemical Properties,Usage,Production
Uses
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].
Biological Activity
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2]. FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1]. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1]. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1]. FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].
in vivo
FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].
| Animal Model: | C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells[2] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; daily; for one months |
| Result: | Significantly inhibited the growth of xenograft tumors. |
References
[1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. [2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.
FIDAS-3 Preparation Products And Raw materials
Raw materials
Preparation Products
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