Boc-C1-PEG3-C4-OH Property

Boiling point:

409.3±35.0 °C(Predicted)

Density 

1.024±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO

form 

Liquid

pka

15.18±0.10(Predicted)

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Boc-C1-PEG3-C4-OH Chemical Properties,Usage,Production

Biological Activity

Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.