Crovalimab
- Product Name
- Crovalimab
- CAS No.
- 1917321-26-6
- Chemical Name
- Crovalimab
- Synonyms
- Crovalimab;Research Grade Crovalimab;Crovalimab (anti-Complement C5);Research Grade Crovalimab (DHB90005)
- CBNumber
- CB88081067
- Formula Weight
- 0
- MOL File
- Mol file
Crovalimab Property
- form
- Liquid
- color
- Colorless to light yellow
Crovalimab Chemical Properties,Usage,Production
Uses
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research[1][2].
in vivo
Crovalimab (SKY59; RO7112689; 20mg/kg; iv; only once at day 0) completely prevents accumulation of plasma C5 in cynomolgus monkeys. SKY59-IgG1 (SG115) shows slower clearance: 1.87mL/day/kg[1].
Crovalimab (20mg/kg; iv; a single dose) stably suppressed complement activity in plasma for 8 weeks[1].
Crovalimab (5mg/kg by iv at day 0 and 2mg/kg by sc at day 7, 21, 35, 49, and 63) causes over 20% of serum hemolytic activity in the cRBC lysis assay to correlate with events such as dysphagia and dramatic increases in lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) levels[1].
References
[1] Taku Fukuzawa, et al. Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases. Sci Rep. 2017 Apr 24;7(1):1080. DOI:10.1038/s41598-017-01087-7
[2] Wioleta M Zelek, et al. Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis. Immunology. 2018 Nov;155(3):396-403. DOI:10.1111/imm.12982
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Raw materials
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