A-134974 DIHYDROCHLORIDE HYDRATE
- Product Name
- A-134974 DIHYDROCHLORIDE HYDRATE
- Chemical Name
- A-134974 DIHYDROCHLORIDE HYDRATE
- Synonyms
- A-134974 DIHYDROCHLORIDE HYDRATE;N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate;N7-[(1'R,2'S,3'R,4'S)-2',3'-DIHYDROXY-4'-AMINOCYCLOPENTYL]-4-AMINO-5-IODOPYRROLOPYRIMIDINE DIHYDROCHLORIDE HYDRATE
- CBNumber
- CB8819039
- Formula Weight
- 0
- MOL File
- Mol file
A-134974 DIHYDROCHLORIDE HYDRATE Property
- form
- solid
- color
- off-white to light tan
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A2846
- Product name
- A-134974 dihydrochloride hydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5MG
- Price
- $359
- Updated
- 2023/06/20
- Product number
- KIN0000955
- Product name
- A-134974 DIHYDROCHLORIDE HYDRATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $908.41
- Updated
- 2021/12/16
A-134974 DIHYDROCHLORIDE HYDRATE Chemical Properties,Usage,Production
Biochem/physiol Actions
A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC50 = 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED50= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED50 = 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED50= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED50 = 100 nmol, i.c.v.) or intraplantar (ED50 >300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED50 values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED50= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.