A-134974 DIHYDROCHLORIDE HYDRATE

Product Name
A-134974 DIHYDROCHLORIDE HYDRATE
Chemical Name
A-134974 DIHYDROCHLORIDE HYDRATE
Synonyms
A-134974 DIHYDROCHLORIDE HYDRATE;N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate;N7-[(1'R,2'S,3'R,4'S)-2',3'-DIHYDROXY-4'-AMINOCYCLOPENTYL]-4-AMINO-5-IODOPYRROLOPYRIMIDINE DIHYDROCHLORIDE HYDRATE
CBNumber
CB8819039
Formula Weight
0
MOL File
Mol file
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A-134974 DIHYDROCHLORIDE HYDRATE Property

form 
solid
color 
off-white to light tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2846
Product name
A-134974 dihydrochloride hydrate
Purity
≥98% (HPLC), solid
Packaging
5MG
Price
$359
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
KIN0000955
Product name
A-134974 DIHYDROCHLORIDE HYDRATE
Purity
95.00%
Packaging
5MG
Price
$908.41
Updated
2021/12/16
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A-134974 DIHYDROCHLORIDE HYDRATE Chemical Properties,Usage,Production

Biochem/physiol Actions

A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC50 = 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED50= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED50 = 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED50= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED50 = 100 nmol, i.c.v.) or intraplantar (ED50 >300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED50 values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED50= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.

A-134974 DIHYDROCHLORIDE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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A-134974 DIHYDROCHLORIDE HYDRATE Suppliers

Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91

A-134974 DIHYDROCHLORIDE HYDRATERelated Search:


  • N7-[(1'R,2'S,3'R,4'S)-2',3'-DIHYDROXY-4'-AMINOCYCLOPENTYL]-4-AMINO-5-IODOPYRROLOPYRIMIDINE DIHYDROCHLORIDE HYDRATE
  • A-134974 DIHYDROCHLORIDE HYDRATE
  • N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate