ChemicalBook > CAS DataBase List > 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-

1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-

Product Name
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
CAS No.
1807758-81-1
Chemical Name
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
Synonyms
SIRT7 inhibitor 97491;SIRT7 inhibitor 97491, 10 mM in DMSO;N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine;1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-;3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine;SIRT7,inhibit,SIRT7 inhibitor 97491,p53 K373/382,Sirtuin,tumor,SIRT-7 inhibitor 97491,deacetylase,Apoptosis,Inhibitor
CBNumber
CB88200837
Molecular Formula
C15H12ClN3O
Formula Weight
285.73
MOL File
1807758-81-1.mol
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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Property

Boiling point:
489.9±55.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
pka
4.30±0.10(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
5mg
Price
$400
Updated
2021/12/16
Axon Medchem
Product number
Axon2968
Product name
SIRT7inhibitor97491
Purity
99%
Packaging
50mg
Price
$522.5
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
50mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
100mg
Price
$2900
Updated
2021/12/16
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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Chemical Properties,Usage,Production

Uses

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

in vivo

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1].

Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Dosage:2 mg/kg
Administration:Intraperitoneally injected; for 3 weeks, except on weekends.
Result:Inhibited cancer growth in vivo.

IC 50

SIRT7: 325 nM (IC50)

References

[1] Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457. DOI:10.1016/j.bbrc.2018.11.120

1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Suppliers

China 30 United States 2 Global 32
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Cochemical Ltd.
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029-86115547 17791676824
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021-51602123
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sales@cochemical.com
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Wuhan chuang he chemical co. LTD
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Hefei fuya biotechnology co. LTD
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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1807758-81-1, 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-Related Search:


  • 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
  • SIRT7 inhibitor 97491
  • N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine
  • SIRT7,inhibit,SIRT7 inhibitor 97491,p53 K373/382,Sirtuin,tumor,SIRT-7 inhibitor 97491,deacetylase,Apoptosis,Inhibitor
  • SIRT7 inhibitor 97491, 10 mM in DMSO
  • 3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine
  • 1807758-81-1